A new Nerve Growth Factor (NGF)-mimetic peptide active on neuropathic pain in rats. (Articolo in rivista)

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  • A new Nerve Growth Factor (NGF)-mimetic peptide active on neuropathic pain in rats. (Articolo in rivista) (literal)
Anno
  • 2008-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1523/JNEUROSCI.5201-07.2008 (literal)
Alternative label
  • Colangelo AM, Bianco MR, Vitagliano L, Cavaliere C, Cirillo G, De Gioia L, Diana D, Colombo D, Redaelli C, Zaccaro L, Morelli G, Papa M, Sarmientos P, Alberghina L, Martegani E., (2008)
    A new Nerve Growth Factor (NGF)-mimetic peptide active on neuropathic pain in rats.
    in The Journal of neuroscience
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Colangelo AM, Bianco MR, Vitagliano L, Cavaliere C, Cirillo G, De Gioia L, Diana D, Colombo D, Redaelli C, Zaccaro L, Morelli G, Papa M, Sarmientos P, Alberghina L, Martegani E., (literal)
Pagina inizio
  • 2698 (literal)
Pagina fine
  • 2709 (literal)
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  • 28 (literal)
Rivista
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  • Pubblicazione su rivista internazionale (literal)
Note
  • ISI Web of Science (WOS) (literal)
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  • 1Laboratorio di Neuroscienze \"R. Levi-Montalcini\" and Dipartimento di Biotecnologie e Bioscienze, Universita` di Milano-Bicocca, 20126 Milan, Italy, 2Laboratorio di Morfologia delle Reti Neuronali, Dipartimento di Medicina Pubblica Clinica e Preventiva, Seconda Universita` di Napoli, 80138 Naples, Italy, 3Centro Interuniversitario di Ricerca sui Peptidi Bioattivi and Dipartimento delle Scienze Biologiche, Universita` di Napoli \"Federico II\" and Istituto di Biostrutture e Bioimmagini, Consiglio Nazionale delle Ricerche, 80138 Naples, Italy, and 4Primm srl, 20132 Milan, Italy (literal)
Titolo
  • A new Nerve Growth Factor (NGF)-mimetic peptide active on neuropathic pain in rats. (literal)
Abstract
  • Analysis of the structure of nerve growth factor (NGF)-tyrosine kinase receptor A (TrkA) complex, site-directed mutagenesis studies and results from chemical modification of amino acid residues have identified loop 1, loop 4, and the N-terminal region of the NGF molecule as the most relevant for its biological activity. We synthesized several peptides mimicking the two loops (1 and 4) linked together with an appropriate spacer, with or without the N-terminal region.TwopeptidesnamedNL1L4 and L1L4 demonstrated goodNGFagonist activity at a concentration as low as 3?M. They induced differentiation of chick dorsal root ganglia and stimulated tyrosine phosphorylation of TrkA, but not TrkB, receptor. In addition L1L4 was able to induce differentiation of PC12 cells. More interestingly, the peptide with the highest \"in vitro\" activity (L1L4) was shown to reduce neuropathic behavior and restore neuronal function in a rat model of peripheral neuropathic pain, thereby suggesting a potential therapeutic role for this NGF-mimetic peptide. (literal)
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