In HspA from Helicobacter pylori vicinal disulfide bridges are a key determinant of domain B structure (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• In HspA from Helicobacter pylori vicinal disulfide bridges are a key determinant of domain B structure (Articolo in rivista) (literal)

Anno

• 2008-01-01T00:00:00+01:00 (literal)

Alternative label

• Loguercio S, Dian C, Flagiello A, Scannella A, Pucci P, Terradot L, Zagari A (2008)
  In HspA from Helicobacter pylori vicinal disulfide bridges are a key determinant of domain B structure
  in FEBS letters (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Loguercio S, Dian C, Flagiello A, Scannella A, Pucci P, Terradot L, Zagari A (literal)

Pagina inizio

• 3537 (literal)

Pagina fine

• 3541 (literal)

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• 582 (literal)

Rivista

• FEBS letters (Rivista)

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• Pubblicazione su rivista internazionale (literal)

Note

• ISI Web of Science (WOS) (literal)

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• a Department of Biological Sciences and CNISM, University of Naples ''Federico II'', Via Mezzocannone 16, I-80134 Naples, Italy b European Synchrotron Radiation Facility, BP 220 F-38043, Grenoble Cedex 9, France c CEINGE - Biotecnologie Avanzate Scarl, Naples, Italy d Department of Organic Chemistry and Biochemistry, University of Naples ''Federico II'', Naples, Italy e IBB istituto di Biostrutture e bioimmagini- CNR (literal)

Titolo

• In HspA from Helicobacter pylori vicinal disulfide bridges are a key determinant of domain B structure (literal)

Abstract

• Helicobacter pylori produces a heat shock protein A (HspA) that is unique to this bacteria. While the first 91 residues (domain A) of the protein are similar to GroES, the last 26 (domain B) are unique to HspA. Domain B contains eight histidines and four cysteines and was suggested to bind nickel. We have produced HspA and two mutants: Cys94Ala and Cys94Ala/Cys111Ala and identified the disulfide bridge pattern of the protein. We found that the cysteines are engaged in three disulfide bonds: Cys51/Cys53, Cys94/Cys111 and Cys95/Cys112 that result in a unique closed loop structure for the domain B. (literal)

Prodotto di

• Institute of biostructure and bioimaging (IBB) (Istituto)
• Determinazione della struttura tridimensionale di biomolecole complesse con tecniche spettroscopiche e cristallografiche (PM.P01.022.001) (Modulo)

Autore CNR

• ADRIANA ZAGARI (Persona)

Insieme di parole chiave

• Parole chiave di "In HspA from Helicobacter pylori vicinal disulfide bridges are a key determinant of domain B structure" (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute of biostructure and bioimaging (IBB) (Istituto)
• Determinazione della struttura tridimensionale di biomolecole complesse con tecniche spettroscopiche e cristallografiche (PM.P01.022.001) (Modulo)

Autore CNR di

• ADRIANA ZAGARI (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• FEBS letters (Rivista)

Insieme di parole chiave di

• Parole chiave di "In HspA from Helicobacter pylori vicinal disulfide bridges are a key determinant of domain B structure" (Insieme di parole chiave)