http://www.cnr.it/ontology/cnr/individuo/prodotto/ID13837
18F-FDG PET/CT, 99mTc-MIBI, and MRI in evaluation of patients with multiple myeloma (Articolo in rivista)
- Type
- Label
- 18F-FDG PET/CT, 99mTc-MIBI, and MRI in evaluation of patients with multiple myeloma (Articolo in rivista) (literal)
- Anno
- 2008-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.2967/jnumed.107.045641 (literal)
- Alternative label
Fonti R; Salvatore B; Quarantelli M; Sirignano C; Segreto S; Petruzziello F; Catalano L; Liuzzi R; Rotoli B; Del Vecchio S; Pace L; Salvatore M (2008)
18F-FDG PET/CT, 99mTc-MIBI, and MRI in evaluation of patients with multiple myeloma
in The Journal of nuclear medicine (1978)
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Fonti R; Salvatore B; Quarantelli M; Sirignano C; Segreto S; Petruzziello F; Catalano L; Liuzzi R; Rotoli B; Del Vecchio S; Pace L; Salvatore M (literal)
- Pagina inizio
- Pagina fine
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- Rivista
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Istituto di Biostrutture e Bioimmagini-CNR, Napoli, Italy; Fondazione SDN-IRCCS, Naples, Italy; Diagnostic Imaging Department,
University Federico II, Naples, Italy; Hematology Department, University Federico II, Naples, Italy (literal)
- Titolo
- 18F-FDG PET/CT, 99mTc-MIBI, and MRI in evaluation of patients with multiple myeloma (literal)
- Abstract
- New imaging techniques have been introduced to assess the extent
and severity of disease in multiple myeloma (MM) patients.
The aim of our study was to compare newer imaging modalities--
such as 18F-FDG PET/CT, 99mTc-methoxyisobutylisonitrile
(99mTc-MIBI) scintigraphy, and MRI--to assess their relative contribution
in the evaluation ofMMpatients at diagnosis. Methods:
Thirty-three newly diagnosed patients with MM were prospectively
studied. Diagnosis and staging were made according to
standard criteria. All patients underwent whole-body 18F-FDG
PET/CT, whole-body 99mTc-MIBI, and MRI of the spine and pelvis
within 10 d, and imaging findings were compared. Results:
18F-FDG PET/CT was positive in 32 patients (16 focal uptake, 3
diffuse uptake, 13 focal and diffuse uptake), 99mTc-MIBI was
positive in 30 patients (6 focal, 11 diffuse, 13 focal and diffuse uptake),
and MRI of the spine and pelvis was positive in 27 patients
(6 focal, 13 diffuse, 8 focal and diffuse uptake). 18F-FDG PET/CT
showed a total of 196 focal lesions (178 in bones and 18 in soft
tissues), of which 121 were in districts other than the spine and
pelvis, whereas 99mTc-MIBI visualized 63 focal lesions (60 in
bones and 3 in soft tissues), of which 53 were in districts other
than the spine and pelvis. In the spinal and pelvic regions, 18FFDG
PET/CT detected 75 focal lesions (35 in spine and 40 in pelvis),
99mTc-MIBI visualized 10 focal lesions (1 in spine and 9 in
pelvis), and MRI detected 51 focal lesions (40 in spine and 11
in pelvis). Conclusion: In whole-body analysis, 18F-FDG PET/
CT performed better than 99mTc-MIBI in the detection of focal lesions,
whereas 99mTc-MIBI was superior in the visualization of
diffuse disease. In the spine and pelvis, MRI was comparable
to 18F-FDG PET/CT and 99mTc-MIBI in the detection of focal
and diffuse disease, respectively. Because myelomatous lesions
may often occur out of spinal and pelvic regions, MRI should be
reserved to the evaluation of bone marrow involvement of these
districts, whereas 18F-FDG PET/CT can significantly contribute
to an accurate whole-body evaluation of MM patients. Finally,
whole-body 99mTc-MIBI, despite its limited capacity in detecting
focal lesions, may be an alternative option when a PET facility is not available. (literal)
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