http://www.cnr.it/ontology/cnr/individuo/prodotto/ID13769
Sestamibi and FDG-PET scans to support diagnosis of jaw osteonecrosis. (Articolo in rivista)
- Type
- Label
- Sestamibi and FDG-PET scans to support diagnosis of jaw osteonecrosis. (Articolo in rivista) (literal)
- Anno
- 2007-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1007/s00277-007-0263-0 (literal)
- Alternative label
Catalano L, Del Vecchio S, Petruzziello F, Fonti R, Salvatore B, Martorelli C, Califano C, Caparrotti G, Segreto S, Pace L, Rotoli B. (2007)
Sestamibi and FDG-PET scans to support diagnosis of jaw osteonecrosis.
in Annals of hematology (Print)
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Catalano L, Del Vecchio S, Petruzziello F, Fonti R, Salvatore B, Martorelli C, Califano C, Caparrotti G, Segreto S, Pace L, Rotoli B. (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Nuclear Medicine Unit, Department of Biomorphological and
Functional Sciences, \"Federico II\" University, Naples, Italy;
Institute of Biostructures and Bioimaging,CNR, Naples, Italy;
Hematology Division,Department of Clinical and
Experimental Medicine,\"Federico II\" University, Naples, Italy (literal)
- Titolo
- Sestamibi and FDG-PET scans to support diagnosis of jaw osteonecrosis. (literal)
- Abstract
- Abstract Osteonecrosis of the maxillary or mandibular
bone is an infrequent but often severe event occurring in
patients who undergo prolonged treatment with bisphosphonates.
Histology is in some cases mandatory to differentiate
it from neoplastic osteolysis, but a biopsy can further
contribute to bone damage. Functional imaging obtained by
a tracer that shows oncotropic properties, such as Tc99msestamibi,
in comparison to a non-tumor-specific substance
such as FDG-PET, can support the differential diagnosis,
thus avoiding invasive procedures. Four patients affected
by multiple myeloma and jaw osteonecrosis were prospectively
evaluated by sestamibi and FDG-PET scans. Local
diagnosis was performed by clinical, radiological and, in
some cases, histological evaluations. Each patient was
studied by Tc99m-sestamibi, performed by planar anterior
and posterior whole-body scans and SPECT of the head and
neck, and by PET/CT. Two nuclear medicine physicians,
unaware of the final diagnosis, reviewed the images. No
sestamibi uptake was evident in the four patients with jaw
osteonecrosis, while FDG-PET/CT showed focal uptake in
all of them. Our study suggests that the combined use of
sestamibi scintigraphy and FDG-PET/CT could support the
clinical diagnosis of oral osteonecrosis avoiding the risks of a
surgical biopsy. Studies on higher number of patients are
necessary to validate these preliminary observations. (literal)
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