Carnosine Interaction with Nitric Oxide and Astroglial Cells Protection. (Articolo in rivista)

Type
Label
  • Carnosine Interaction with Nitric Oxide and Astroglial Cells Protection. (Articolo in rivista) (literal)
Anno
  • 2007-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1002/jnr.21365 (literal)
Alternative label
  • Vincenzo Giuseppe Nicoletti, Anna Maria Santoro; Giulia Grasso; Laura Irene Vagliasindi; Maria Laura Giuffrida; Cristian Cuppari; Vittoria Spina Purrello;Anna Maria Giuffrida Stella.; Enrico Rizzarelli. (2007)
    Carnosine Interaction with Nitric Oxide and Astroglial Cells Protection.
    in Journal of neuroscience research; WILEY-LISS, DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 (Stati Uniti d'America)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Vincenzo Giuseppe Nicoletti, Anna Maria Santoro; Giulia Grasso; Laura Irene Vagliasindi; Maria Laura Giuffrida; Cristian Cuppari; Vittoria Spina Purrello;Anna Maria Giuffrida Stella.; Enrico Rizzarelli. (literal)
Pagina inizio
  • 2239 (literal)
Pagina fine
  • 2245 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 85 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#descrizioneSinteticaDelProdotto
  • Articolo su rivista internazionale (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Nicoletti V. G.;Vagliasindi L.I.; Giuffrida M.L.; Cuppari C.; Purrello V.S.; Stella A.M.;Dipartimento di Scienze Chimiche, Universita degli Studi di Catania, Catania, Italy (literal)
Titolo
  • Carnosine Interaction with Nitric Oxide and Astroglial Cells Protection. (literal)
Abstract
  • The neuropeptide carnosine (b-alanyl-L-histidine; AH), present in postmitotic mammalian tissues (brain, skeletal muscle), is involved in many processes of cellular defense such as free-radical detoxification, inhibition of protein crosslinking, and glycation. Neuronal protection by carnosine through inhibition of b-amyloid peptide aggregation has been demonstrated. Carnosine protection against peroxynitrite damage is particularly relevant, but until now there has been no evidence of any direct interaction with nitric oxide. In this study we examined the protection that carnosine provides against nitric oxide (NO)-induced cell death in primary rat astroglial cell cultures treated with lipopolysaccharide (LPS) and interferon gamma (INFc), a well-known neurotoxic proinflammatory condition. A correlation was found between cell protection and NO free-radical scavenging activity of carnosine. Moreover, by competitive spectrophotometric measurement and electrospray mass spectrometry analysis in cell-free experiments, we demonstrated a direct interaction of the dipeptide with NO. A comparison of carnosine with its homologues or derivatives (homocarnosine and carcinine) as well as with its amino acid constituents (L-histidine and b-alanine) highlighted that only histidine showed significant scavenging activity. Therefore, carnosine shows direct NO-trapping ability and may be a valuable multifunctional molecule in the treatment of neurodegenerative disorders. (literal)
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