http://www.cnr.it/ontology/cnr/individuo/prodotto/ID13763
Carnosine Interaction with Nitric Oxide and Astroglial Cells Protection. (Articolo in rivista)
- Type
- Label
- Carnosine Interaction with Nitric Oxide and Astroglial Cells Protection. (Articolo in rivista) (literal)
- Anno
- 2007-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1002/jnr.21365 (literal)
- Alternative label
Vincenzo Giuseppe Nicoletti, Anna Maria Santoro; Giulia Grasso; Laura Irene Vagliasindi; Maria Laura Giuffrida; Cristian Cuppari; Vittoria Spina Purrello;Anna Maria Giuffrida Stella.; Enrico Rizzarelli. (2007)
Carnosine Interaction with Nitric Oxide and Astroglial Cells Protection.
in Journal of neuroscience research; WILEY-LISS, DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 (Stati Uniti d'America)
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Vincenzo Giuseppe Nicoletti, Anna Maria Santoro; Giulia Grasso; Laura Irene Vagliasindi; Maria Laura Giuffrida; Cristian Cuppari; Vittoria Spina Purrello;Anna Maria Giuffrida Stella.; Enrico Rizzarelli. (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#descrizioneSinteticaDelProdotto
- Articolo su rivista internazionale (literal)
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Nicoletti V. G.;Vagliasindi L.I.; Giuffrida M.L.; Cuppari C.; Purrello V.S.; Stella A.M.;Dipartimento di Scienze Chimiche, Universita degli Studi di Catania, Catania, Italy (literal)
- Titolo
- Carnosine Interaction with Nitric Oxide and Astroglial Cells Protection. (literal)
- Abstract
- The neuropeptide carnosine (b-alanyl-L-histidine; AH),
present in postmitotic mammalian tissues (brain, skeletal
muscle), is involved in many processes of cellular
defense such as free-radical detoxification, inhibition of
protein crosslinking, and glycation. Neuronal protection
by carnosine through inhibition of b-amyloid peptide
aggregation has been demonstrated. Carnosine protection
against peroxynitrite damage is particularly relevant,
but until now there has been no evidence of any
direct interaction with nitric oxide. In this study we
examined the protection that carnosine provides
against nitric oxide (NO)-induced cell death in primary
rat astroglial cell cultures treated with lipopolysaccharide
(LPS) and interferon gamma (INFc), a well-known
neurotoxic proinflammatory condition. A correlation
was found between cell protection and NO free-radical
scavenging activity of carnosine. Moreover, by competitive
spectrophotometric measurement and electrospray
mass spectrometry analysis in cell-free experiments,
we demonstrated a direct interaction of the dipeptide
with NO. A comparison of carnosine with its homologues
or derivatives (homocarnosine and carcinine) as
well as with its amino acid constituents (L-histidine and
b-alanine) highlighted that only histidine showed significant
scavenging activity. Therefore, carnosine shows
direct NO-trapping ability and may be a valuable multifunctional
molecule in the treatment of neurodegenerative
disorders. (literal)
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