New peptide nucleic acid analogues: synthesis and applications (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• New peptide nucleic acid analogues: synthesis and applications (Articolo in rivista) (literal)

Anno

• 2007-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1517/14712598.7.8.1219 (literal)

Alternative label

• Pensato, Soccorsa; Saviano, Michele; Romanelli, Alessandr (2007)
  New peptide nucleic acid analogues: synthesis and applications
  in Expert opinion on biological therapy
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Pensato, Soccorsa; Saviano, Michele; Romanelli, Alessandr (literal)

Pagina inizio

• 1219 (literal)

Pagina fine

• 1232 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 7 (literal)

Rivista

• Expert opinion on biological therapy (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#descrizioneSinteticaDelProdotto

• Pubblicazione su rivista internazionale (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Univ Naples Federico 2, Fac Sci Biotecnol, Dipartimento Sci Biol, I-80134 Naples, Italy CNR, Ist Biostrut & Bioimmagini, I-80134 Naples, Italy (literal)

Titolo

• New peptide nucleic acid analogues: synthesis and applications (literal)

Abstract

• Peptide nucleic acids are oligonucleotide mimics characterised by high chemical and enzymatic stability, high specificity and affinity toward complementary DNA/RNA. The lack of charge and polar groups in the backbone decrease their solubility in aqueous environment and their ability to cross cell membranes, reducing their performance in in vivo applications. To improve solubility, increase affinity and specificity of binding and to control recognition between nucleic acids, several analogues bearing modifications on the nucleobase, nucleobase-backbone linker and on the backbone were synthesised. This paper describes the synthesis and applications of Peptide nucleic acid analogues and discusses the potential of analogues for which no application is reported. (literal)

Prodotto di

• Sviluppo di sistemi molecolari per il delivery di farmaci e diagnostici (PM.P01.003.003) (Modulo)
• Institute of biostructure and bioimaging (IBB) (Istituto)

Autore CNR

• ALESSANDRA ROMANELLI (Unità di personale esterno)
• MICHELE SAVIANO (Persona)

Incoming links:

Autore CNR di

• MICHELE SAVIANO (Persona)
• ALESSANDRA ROMANELLI (Unità di personale esterno)

Prodotto

• Institute of biostructure and bioimaging (IBB) (Istituto)
• Sviluppo di sistemi molecolari per il delivery di farmaci e diagnostici (PM.P01.003.003) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Expert opinion on biological therapy (Rivista)