Nuclear imaging in cancer theranostics (Articolo in rivista)

  • Nuclear imaging in cancer theranostics (Articolo in rivista) (literal)
  • 2007-01-01T00:00:00+01:00 (literal)
Alternative label
  • Del Vecchio S; Zannetti A; Fonti R; Pace L; Salvatore M (2007)
    Nuclear imaging in cancer theranostics
    in The Quarterly journal of nuclear medicine and molecular imaging (Testo stamp.)
  • Del Vecchio S; Zannetti A; Fonti R; Pace L; Salvatore M (literal)
Pagina inizio
  • 152 (literal)
Pagina fine
  • 163 (literal)
  • 51 (literal)
  • 12 (literal)
  • 2 (literal)
  • ISI Web of Science (WOS) (literal)
  • Istituto di Biostrutture e Bioimmagini, Dipartimento di Scienze Biomorfologiche e Funzionali (literal)
  • Nuclear imaging in cancer theranostics (literal)
  • The combination of a diagnostic test with a therapeutic entity is termed theranostics. The diagnostic test aims at identifying patients who will likely benefit from a specific therapeutic intervention, fail to respond or eventually manifest side effects to a given drug. The appropriate selection of patients for innovative therapies would promote an enrichment of patient population that can potentiate clinical trials and eventually accelerate the drug development process. For these reasons many drug companies adopted a theranostic approach as a new and promising avenue for drug development. From an historical perspective, the concepts underlying the theranostic strategy are well known in nuclear medicine and constituted the basis of many nuclear imaging procedures currently used in clinical practice. Nevertheless the adoption of these concepts by regulatory authorities is a real progress and reflects the remarkable advances in the development of drugs against molecular targets. In this respect, the oncological field provides the strongest evidence of the clinical need to link diagnostics to therapeutics. Here we review the contribution that non-invasive nuclear imaging may give to cancer theranostics and report prominent examples. (literal)
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