Presence of FLT3 mutations does not impair stem cell mobilization and feasibility of autologous peripheral blood stem cell transplantation in acute myeloid leukemia (Articolo in rivista)

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  • Presence of FLT3 mutations does not impair stem cell mobilization and feasibility of autologous peripheral blood stem cell transplantation in acute myeloid leukemia (Articolo in rivista) (literal)
Anno
  • 2006-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.bbmt.2006.05.017 (literal)
Alternative label
  • Ferrara F. ; Palmieri S. ; Pollio F. ; Lo Pardo C. ; Graziano D. ; Celentano M. ; D'Amico M.R. ; Vicari L. ; Izzo B. ; Pane F. (2006)
    Presence of FLT3 mutations does not impair stem cell mobilization and feasibility of autologous peripheral blood stem cell transplantation in acute myeloid leukemia
    in Biology of blood and marrow transplantation; ELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS, AMSTERDAM (Paesi Bassi)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Ferrara F. ; Palmieri S. ; Pollio F. ; Lo Pardo C. ; Graziano D. ; Celentano M. ; D'Amico M.R. ; Vicari L. ; Izzo B. ; Pane F. (literal)
Pagina inizio
  • 981 (literal)
Pagina fine
  • 986 (literal)
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  • 12 (literal)
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  • 9 (literal)
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  • copu (literal)
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Cardarelli Hosp, Div Haematol, Naples, Italy ; Cardarelli Hosp, Stem Cell Transplantat Unit, Naples, Italy ; Cardarelli Hosp, Transfus Med Serv, Naples, Italy ; Cardarelli Hosp, Serv Med Genet, Naples, Italy ; Univ Naples Federico II, CEINGE, Naples, Italy (literal)
Titolo
  • Presence of FLT3 mutations does not impair stem cell mobilization and feasibility of autologous peripheral blood stem cell transplantation in acute myeloid leukemia (literal)
Abstract
  • Fetal liver tyrosine kinase 3 (FLT3) mutations represent a powerful prognostic indicator in acute myeloid leukemia (AML). Further, interaction between FLT3 and its ligand plays a role in normal hematopoiesis. Accordingly, FLT3 mutations may affect mobilization of peripheral blood stem cells (PBSCs) and feasibility of autologous stem cell transplantation (ASCT) in AML. We analyzed the effect of FLT3 mutations on mobilization of CD34(+) cells and on PBASCT feasibility from 111 patients with AML, with a median age of 58 years and normal karyotype. Overall, 23 patients (21%) had FLT3 mutations. The complete remission rate was 74% and was not influenced by FLT3 mutations (73% for patients with FLT3(-) and 78% for those with FLT3(+); P = .78). The successful mobilization rate was 79% and was comparable for patients with FLT3(-) and with FLT3(+) (P = .42). Median numbers of CD34(+) cells collected were 7.6 x 10(6)/kg and 7.1 x 10(6)/kg for patients with FLT3(-) and those with FLT3(+), respectively (P = .64). Among 73 patients evaluated for mobilization, feasibility of ASCT was 71%, and there was no difference between patients with FLT3(-) (74%) and those with FLT3(+) (61%), P = .43. We conclude that the FLT3 mutations have no influence on mobilization of CD34(+) cells or on feasibility of PBASCT in patients with AML and normal karyotype. (C) 2006 American Society for Blood and Marrow Transplantation. (literal)
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