Modifications of brain tissue volumes in facioscapulohumeral dystrophy (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Modifications of brain tissue volumes in facioscapulohumeral dystrophy (Articolo in rivista) (literal)

Anno

• 2006-01-01T00:00:00+01:00 (literal)

Alternative label

• Quarantelli M; Lanzillo R; Del Vecchio W; Mollica C; Prinster A; Iadiccio L; Iodice V; Santoro L; Salvatore M. (2006)
  Modifications of brain tissue volumes in facioscapulohumeral dystrophy
  in NeuroImage (Orlando Fla., Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Quarantelli M; Lanzillo R; Del Vecchio W; Mollica C; Prinster A; Iadiccio L; Iodice V; Santoro L; Salvatore M. (literal)

Pagina inizio

• 1237 (literal)

Pagina fine

• 1242 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 32 (literal)

Rivista

• NeuroImage (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• istituto di biostrutture e bioimmagini (literal)

Titolo

• Modifications of brain tissue volumes in facioscapulohumeral dystrophy (literal)

Abstract

• Facioscapulohumeral muscular dystrophy (FSHD), a pathology primarily characterized by involvement of the muscles in the face, shoulder and upper arm, can be associated to several CNS disorders, including sensorineural hearing deficits, schizophrenia, epilepsy and mental retardation. Aim of our study was to verify if brain tissue volumes, as measured by segmentation of MRI studies, are altered in FSHD. Volumes of gray matter (GM), white matter (WM), and cerebrospinal fluid (CSF) were compared, taking into account head size age and sex, both globally (by multiple regression analysis) and regionally (by optimized voxel-based morphometry-VBM) in thirty patients with FSHD and 39 normal subjects (NS). FSHD patients had significantly lower GM volumes and higher CSF volumes (P < 10?4). GM loss showed a borderline correlation with clinical severity (P < 0.05). Brain tissue volumes did not correlate with disease duration, size of the genetic deletion, age at onset and the presence at MRI of WM hyperintensities (detected in 4/22 patients). At VBM three clusters of GM loss were detected, in the left precentral cortex (Brodmann areas 6, 2 and 44, P < 10?14 corrected for multiple comparisons at cluster level), in the anterior cingulate (Brodmann areas 33, 24 and 11, P < 10?4) and in the right frontopolar region (Brodmann area 10, P < 5I10?3). To the best of our knowledge, this is the first study to demonstrate a reduction in GM volume in FSHD. We hypothesize that localized GM loss in FSHD is the consequence of a selective involvement of specific CNS structures. (literal)

Prodotto di

• Messa a punto di Metodiche Diagnostiche innovative di Imaging Quantitativo (ME.P06.004.002) (Modulo)
• Institute of biostructure and bioimaging (IBB) (Istituto)

Autore CNR

• MARCO SALVATORE (Persona)
• MARIO QUARANTELLI (Persona)
• WALTER DEL VECCHIO (Unità di personale interno)
• ANNA PRINSTER (Unità di personale interno)

Incoming links:

Autore CNR di

• MARIO QUARANTELLI (Persona)
• MARCO SALVATORE (Persona)
• ANNA PRINSTER (Unità di personale interno)
• WALTER DEL VECCHIO (Unità di personale interno)

Prodotto

• Institute of biostructure and bioimaging (IBB) (Istituto)
• Messa a punto di Metodiche Diagnostiche innovative di Imaging Quantitativo (ME.P06.004.002) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• NeuroImage (Rivista)