Dynamic interaction between PARP-1, PCNA and p21waf1cip1. (Contributo in volume (capitolo o saggio))

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Label
  • Dynamic interaction between PARP-1, PCNA and p21waf1cip1. (Contributo in volume (capitolo o saggio)) (literal)
Anno
  • 2006-01-01T00:00:00+01:00 (literal)
Alternative label
  • Prosperi E, Scovassi AI (2006)
    Dynamic interaction between PARP-1, PCNA and p21waf1cip1.
    Landes Bioscience, Austin (Stati Uniti d'America) in Poly(ADP-Rybosyl)ation, 2006
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Prosperi E, Scovassi AI (literal)
Pagina inizio
  • 67 (literal)
Pagina fine
  • 74 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni
  • CAPITOLO SU INVITO (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#citta
  • Austin, TX, USA (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#titoloVolume
  • Poly(ADP-Rybosyl)ation (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note
  • pp. 67-74 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#descrizioneSinteticaDelProdotto
  • Poly(ADP-ribose) polymerase (PARP-1) plays a crucial role in DNA repair and interacts with many DNA replication/repair factors, including the Proliferating Cell Nuclear Antigen (PCNA), a protein involved in many DNA transactions. The association between these proteins in vitro results in the inhibition of PARP-1 activity and of PCNA-dependent DNA synthesis carried out by DNA polymerase d. In vivo, the interaction of the two proteins has been shown to increase after DNA damage. The activity of PCNA is regulated by p21waf1/cip1, which binds the interdomain connector loop of PCNA in the same region involved in the interaction of PCNA with DNA polymerase d. This feature enables p21 to compete with DNA polymerase d to regulate the differential inhibition of DNA replication vs. DNA repair. The finding that PARP-1 is associated with both PCNA and p21 suggests a possible cooperation of PARP-1 and p21 in regulating the functions of PCNA during DNA replication/repair. (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • IGM-CNR (literal)
Titolo
  • Dynamic interaction between PARP-1, PCNA and p21waf1cip1. (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#inCollana
  • Poly(ADP-ribosyl)ation (Burkle A. ed) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#isbn
  • 0-387-33371-1 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autoriVolume
  • Alexander Burkle (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#curatoriVolume
  • Alexander Burkle (literal)
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