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Microenvironment influence on stem cells: Pre-carcinogenesis features in the liver of transgenic MMTV-neu (erbB-2) mice bearing mammary tumor. (Monografia o trattato scientifico)

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Microenvironment influence on stem cells: Pre-carcinogenesis features in the liver of transgenic MMTV-neu (erbB-2) mice bearing mammary tumor. (Monografia o trattato scientifico) (literal)

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Freitas I., Fracchiolla S., Bertone R., Vaccarone R., Baronzio G.F., Bertone V., Sacco M.G., Barni S., Gerzeli G. (2005)
Microenvironment influence on stem cells: Pre-carcinogenesis features in the liver of transgenic MMTV-neu (erbB-2) mice bearing mammary tumor.
Istituto Lombardo Acc. di Scienze e Lettere, Milano, 2005
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Freitas I., Fracchiolla S., Bertone R., Vaccarone R., Baronzio G.F., Bertone V., Sacco M.G., Barni S., Gerzeli G. (literal)

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Altogether, these alterations might be caused by the sustained stress induced by the tumor on the liver. It is assumed that hemopoietic precursors observed in the liver sinusoids were recruited by the tumor for angiogenesis purposes, but also found in the liver a permissive environment for arrest and differentiation. It is recalled that the fate of stem cells/progenitors depends on the environment reached and that cancer is believed to be a stem cell-derived pathology. It is concluded that the final outcome of the activation of a presumably ancestral and nonspecific repair system can be diversified according to the final destination of the activated precursors. (literal)

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This paper calls the attention for a particular risk of the use of marrow-derived stem cells in regenerative medicine, whose plasticity is recalled, and namely that of inducing a tumor in the organ intended to be repaired or in another indirectly injured organ. These considerations were motivated by our recent research with a transgenic model of human mammary cancer, MMTV-neu (erbB-2) adult mice, where we detected features or early hepatocarcinogenesis. Remarkably, the liver reaction was lobular-zone dependent. In portal (and sub-capsular) sinusoids CD34+ cells were abundant and hematopoiesis built up, liver cell progenitors were activated giving a ductular reaction, and hepatocytes expressed CK19, AFP and GGT. Elsewhere large dysplastic hepatocytes were frequent. The fetal-like microenvironment in the portal areas might be better suited than the adult one for the recruitment, migration and differentiation of liver cell precursors including marrow-derived precursors. By contrast, large cell dysplasia suggests polyploidy and hence terminal differentiation. (literal)

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Freitas, Fracchiolla, Bertone, Vaccarone, Bertone, Barni, Gerzeli: Department of Animal Biology and CNR Institute of Molecular Genetics, Session of Histochemistry and Cytometry, University of Pavia; Baronzio: ASL 01, Legnano; Sacco: Institute of Biomedical Technologies, CNR-ITB, University of Milano. Italy. Freitas, Fracchiolla, Bertone, Vaccarone, Bertone, Barni, Gerzeli: Department of Animal Biology and CNR Institute of Molecular Genetics, Session of Histochemistry and Cytometry, University of Pavia; Baronzio: ASL 01, Legnano; Sacco: Institute of Biomedical Technologies, CNR-ITB, University of Milano. Italy. (literal)

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Microenvironment influence on stem cells: Pre-carcinogenesis features in the liver of transgenic MMTV-neu (erbB-2) mice bearing mammary tumor. (literal)

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