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Melatonin limits ischemia-reperfusion injury: implications for aging and organ transplantation. (Contributo in volume (capitolo o saggio))

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Melatonin limits ischemia-reperfusion injury: implications for aging and organ transplantation. (Contributo in volume (capitolo o saggio)) (literal)

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Reiter R.J., Tan D-X, Vairetti M., Maldonado M.D., Freitas I. (2005)
Melatonin limits ischemia-reperfusion injury: implications for aging and organ transplantation.
Nova Science Publishers, New York, 2005
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Since the frequency of ischemia/reperfusion increases with advancing age and endogenous melatonin levels drop during the same interval, the findings have obvious implications for the elderly. Finally, the evidence presented makes a strong argument for the use of melatonin in organ transplantation, a procedure which generates large numbers of toxic free radical and related reactants. (literal)

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This brief review summarizes the published literature related to the efficacy of melatonin in preventing molecular, structural, and functional damage to organs when they are subjected to ischemia and reperfusion. The literature supporting melatonin as a protective agent against the damage following the interruption and re-establishment of blood flow has accumulated essentially within the last decade commensurate with the discoveries of melatonins free radical scavenging and antioxidant potential. Whereas the bulk of the studies have examined the role of melatonin in combating cardiac (in experimental heart attack) and neural (in experimental stroke) damage during and after ischemia/reperfusion, the indole has also been widely tested as a preserver of structure and function in other organs deprived of and then re-supplied with oxygenated blood. These reports and also reviewed herein. While melatonins high efficacy as a direct free radical scavenger and indirect antioxidant are the usual reasons given for its protective effects, there are a number of other actions of the indole that likely improves its ability to limit free radical mutilation. That information is also presented in this report. (literal)

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Reiter, Tan, Maldonado: Department of Cellular and Structural Biology; The University of Texas Health Science Center, San Antonio, TX, USA; Vairetti: Internal Medicine and Therapeutics, University of Pavia; Freitas: Department of Animal Biology and CNR Institute of Molecular Genetics, Session of Histochemistry and Cytometry, University of Pavia (literal)

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