http://www.cnr.it/ontology/cnr/individuo/prodotto/ID13482
Stereotaxy-based regional brain volumetry applied to segmented MRI: validation and results in deficit and nondeficit schizophrenia. (Articolo in rivista)
- Type
- Label
- Stereotaxy-based regional brain volumetry applied to segmented MRI: validation and results in deficit and nondeficit schizophrenia. (Articolo in rivista) (literal)
- Anno
- 2002-01-01T00:00:00+01:00 (literal)
- Alternative label
Quarantelli M., Larobina M., Volpe U., Amati G., Tedeschi E., Ciarmiello A., Brunetti A., Galderisi S., Alfano B. (2002)
Stereotaxy-based regional brain volumetry applied to segmented MRI: validation and results in deficit and nondeficit schizophrenia.
in NeuroImage (Orlando Fla., Print)
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Quarantelli M., Larobina M., Volpe U., Amati G., Tedeschi E., Ciarmiello A., Brunetti A., Galderisi S., Alfano B. (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Note
- ISI Web of Science (WOS) (literal)
- Titolo
- Stereotaxy-based regional brain volumetry applied to segmented MRI: validation and results in deficit and nondeficit schizophrenia. (literal)
- Abstract
- A method for postprocessing of segmented routine brain MRI studies
providing automated definition of major structures (frontal, parietal,
occipital, and temporal lobes; cerebellar hemispheres; and lateral
ventricles) according to the Talairach atlas is presented. The method was
applied to MRI studies from 25 normal subjects (NV), 14 patients with
deficit schizophrenia (DS), and 14 with nondeficit schizophrenia (NDS),
to
evaluate their gray matter and CSF regional volumes. The two patient
groups did not differ in mean age at illness onset, duration of illness,
severity of psychotic symptoms, or disorganization; DS had more severe
avolition and worse social functioning than NDS. For validation purposes,
brain structures were manually outlined on original MR images in 10
studies, thus obtaining reference measures. Manual and automated measures
were repeated 1 month apart to measure reproducibilities of both methods.
The automated method required less than 1 min/operator per study vs more
than 30 min for manual assessment. Mean absolute difference per structure
between the two techniques was 4.8 ml. Overall reproducibility did not
significantly differ between the two methods. In subjects with
schizophrenia, a significant decrease in GM and increase in CSF were
found. GM loss was confined to frontal and temporal lobes. Lateral
ventricles were significantly larger bilaterally in NDS compared to NV
and
only on the right in NDS compared to DS. The finding of greater
structural
brain abnormalities in NDS adds to the evidence that deficit
schizophrenia
does not represent just the more severe end of the schizophrenia
continuum. (literal)
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