http://www.cnr.it/ontology/cnr/individuo/prodotto/ID13480
Potential reduction of the incidence of radiation-induced second cancers by using proton beams in the treatment of pediatric tumors (Articolo in rivista)
- Type
- Label
- Potential reduction of the incidence of radiation-induced second cancers by using proton beams in the treatment of pediatric tumors (Articolo in rivista) (literal)
- Anno
- 2002-01-01T00:00:00+01:00 (literal)
- Alternative label
Miralbell R., Lomax A., Cella L., Schneider U. (2002)
Potential reduction of the incidence of radiation-induced second cancers by using proton beams in the treatment of pediatric tumors
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Miralbell R., Lomax A., Cella L., Schneider U. (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- IBB- CNR
Paul Scherrer Institute, Villigen, Zurich
Hopital Cantonal de Geneve, Geneve (literal)
- Titolo
- Potential reduction of the incidence of radiation-induced second cancers by using proton beams in the treatment of pediatric tumors (literal)
- Abstract
- PURPOSE: To assess the potential influence of improved dose distribution
with proton beams compared to conventional or intensity-modulated (IM) X-
ray beams on the incidence of treatment-induced secondary cancers in
pediatric oncology. METHODS AND MATERIALS: Two children, one with a
parameningeal rhabdomyosarcoma (RMS) and a second with a medulloblastoma,
were used as models for the purpose of this study. After defining the
target and critical structures, treatment plans were calculated and
optimized, four for the RMS case (conventional X-ray, IM X-rays, protons,
and IM protons) and three for the irradiation of the spinal axis in
medulloblastoma (conventional X-ray, IM X-rays, protons). Secondary
cancer
incidence was estimated using a model based on Publication No. 60 of the
International Commission on Radiologic Protection. This model allowed
estimation of absolute risks of secondary cancer for each treatment plan
based on dose-volume distributions for the nontarget organs. RESULTS:
Proton beams reduced the expected incidence of radiation-induced
secondary
cancers for the RMS patient by a factor of >or=2 and for the
medulloblastoma case by a factor of 8 to 15 when compared with either IM
or conventional X-ray plans. CONCLUSIONS: The potential for a significant
reduction in secondary cancers with pediatric cancers after using proton
beams (forward planned or IM) in the treatment of RMS and MBD in children
and adolescents represents an additional argument supporting the
development of proton therapy for most radiotherapy indications in
pediatric oncology. (literal)
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