http://www.cnr.it/ontology/cnr/individuo/prodotto/ID13463
Design of Stable a-Helical Arrays from an Idealized TPR Motif. (Articolo in rivista)
- Type
- Label
- Design of Stable a-Helical Arrays from an Idealized TPR Motif. (Articolo in rivista) (literal)
- Anno
- 2003-01-01T00:00:00+01:00 (literal)
- Alternative label
Main, Ewan R. G.; Xiong, Yong; Cocco, Melanie J.; D'Andrea, Luca; Regan, Lynne. (2003)
Design of Stable a-Helical Arrays from an Idealized TPR Motif.
in Structure (Lond.)
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Main, Ewan R. G.; Xiong, Yong; Cocco, Melanie J.; D'Andrea, Luca; Regan, Lynne. (literal)
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- Pagina fine
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- Rivista
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- 1. Yale Univeristy, Dept Molecular Biophysics and Biochemistry
2. CNR, Istituto di Biostrutture e Bioimmagini (literal)
- Titolo
- Design of Stable a-Helical Arrays from an Idealized TPR Motif. (literal)
- Abstract
- The tetratricopeptide repeat (TPR) is a 34-amino acid a-helical motif that occurs in over 300 different proteins. In the different proteins, three to sixteen or more TPR motifs occur in tandem arrays and function to mediate protein-protein interactions. The binding specificity of each TPR protein is different, although the underlying structural motif is the same. Here we describe a statistical approach to the design of an idealized TPR motif. We present the high-resoln. X-ray crystal structures (to 1.55 and 1.6 .ANG.) of designed TPR proteins and describe their soln. properties and stability. A detailed anal. of these structures provides an understanding of the TPR motif, how it is repeated to give helical arrays with different superhelical twists, and how a very stable framework may be constructed for future functional designs. (literal)
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