Design of Stable a-Helical Arrays from an Idealized TPR Motif. (Articolo in rivista)

Type
Label
  • Design of Stable a-Helical Arrays from an Idealized TPR Motif. (Articolo in rivista) (literal)
Anno
  • 2003-01-01T00:00:00+01:00 (literal)
Alternative label
  • Main, Ewan R. G.; Xiong, Yong; Cocco, Melanie J.; D'Andrea, Luca; Regan, Lynne. (2003)
    Design of Stable a-Helical Arrays from an Idealized TPR Motif.
    in Structure (Lond.)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Main, Ewan R. G.; Xiong, Yong; Cocco, Melanie J.; D'Andrea, Luca; Regan, Lynne. (literal)
Pagina inizio
  • 497 (literal)
Pagina fine
  • 508 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 11 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1. Yale Univeristy, Dept Molecular Biophysics and Biochemistry 2. CNR, Istituto di Biostrutture e Bioimmagini (literal)
Titolo
  • Design of Stable a-Helical Arrays from an Idealized TPR Motif. (literal)
Abstract
  • The tetratricopeptide repeat (TPR) is a 34-amino acid a-helical motif that occurs in over 300 different proteins. In the different proteins, three to sixteen or more TPR motifs occur in tandem arrays and function to mediate protein-protein interactions. The binding specificity of each TPR protein is different, although the underlying structural motif is the same. Here we describe a statistical approach to the design of an idealized TPR motif. We present the high-resoln. X-ray crystal structures (to 1.55 and 1.6 .ANG.) of designed TPR proteins and describe their soln. properties and stability. A detailed anal. of these structures provides an understanding of the TPR motif, how it is repeated to give helical arrays with different superhelical twists, and how a very stable framework may be constructed for future functional designs. (literal)
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