Structural insight into the antibiotic action of telithromycin against resistant mutants. (Articolo in rivista)

Type
Label
  • Structural insight into the antibiotic action of telithromycin against resistant mutants. (Articolo in rivista) (literal)
Anno
  • 2003-01-01T00:00:00+01:00 (literal)
Alternative label
  • Berisio, Rita; Harms, Joerg; Schluenzen, Frank; Zarivach, Raz; Hansen, Harly A. S.; Fucini, Paola; Yonath, Ada. (2003)
    Structural insight into the antibiotic action of telithromycin against resistant mutants.
    in Journal of bacteriology (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Berisio, Rita; Harms, Joerg; Schluenzen, Frank; Zarivach, Raz; Hansen, Harly A. S.; Fucini, Paola; Yonath, Ada. (literal)
Pagina inizio
  • 4276 (literal)
Pagina fine
  • 4279 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 185 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Titolo
  • Structural insight into the antibiotic action of telithromycin against resistant mutants. (literal)
Abstract
  • he crystal structure of the ketolide telithromycin bound to the Deinococcus radiodurans large ribosomal subunit shows that telithromycin blocks the ribosomal exit tunnel and interacts with domains II and V of the 23S RNA. Comparisons to other clin. relevant macrolides provided structural insights into its enhanced activity against macrolide-resistant strains. (literal)
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