ONYX-015 enhances radiation-induced death of human anaplastic thyroid carcinoma cells. (Articolo in rivista)

Type
Label
  • ONYX-015 enhances radiation-induced death of human anaplastic thyroid carcinoma cells. (Articolo in rivista) (literal)
Anno
  • 2003-01-01T00:00:00+01:00 (literal)
Alternative label
  • Portella G, Pacelli R, Libertini S, Cella L, Vecchio G, Salvatore M, Fusco A (2003)
    ONYX-015 enhances radiation-induced death of human anaplastic thyroid carcinoma cells.
    in The Journal of clinical endocrinology and metabolism
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Portella G, Pacelli R, Libertini S, Cella L, Vecchio G, Salvatore M, Fusco A (literal)
Pagina inizio
  • 5027 (literal)
Pagina fine
  • 5032 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 88 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita di Napoli Federico II,Institute of Biostructure and Bioimaging of National Counsil Tesarch, Naples, Italy (literal)
Titolo
  • ONYX-015 enhances radiation-induced death of human anaplastic thyroid carcinoma cells. (literal)
Abstract
  • ONYX-015 is a genetically modified adenovirus with a deletion of the E1B early gene and therefore is designed to replicate preferentially in p53-mutated cells causing their death. We previously demonstrated that the ONYX-015 virus kills anaplastic thyroid carcinoma (ATC) cells and enhances the antineoplastic effects of doxorubicin and paclitaxel. Here we report that ONYX-015 increased the cytopathic effect of radiotherapy in three ATC cell lines. In fact, ONYX-015 and radiation induced a significant cytopathic effect on ATC cells. DNA fragmentation analysis showed that ATC ONYX-015-treated cells were very sensitive to radiation-induced apoptosis. In addition, low doses of ONYX-015 associated with a single radiation dose of 10 Gy delayed the growth of a xenograft tumor induced by ARO cells in athymic mice. Our results suggest that the combination of ONYX-015 and radiotherapy should be considered for experimental trials in patients with anaplastic thyroid carcinoma. (literal)
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