From micro- to femto-moles, from small to giant molecules: the route of modern Mass Spectrometry (Contributo in volume (capitolo o saggio))

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  • From micro- to femto-moles, from small to giant molecules: the route of modern Mass Spectrometry (Contributo in volume (capitolo o saggio)) (literal)
Anno
  • 2011-01-01T00:00:00+01:00 (literal)
Alternative label
  • A.Palmigiano, D.Garozzo (2011)
    From micro- to femto-moles, from small to giant molecules: the route of modern Mass Spectrometry
    , Gargnano (BS), 2011
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • A.Palmigiano, D.Garozzo (literal)
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  • Gargnano (BS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note
  • June 13-17, 2011. 264-279 (2011). (literal)
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  • Abstract: The definition of a mass spectrometer from the America Society for Mass Spectrometry (ASMS) is: \"A mass spectrometer is an instrument that measures the masses of individual molecules thathave been converted to ions; i. e. molecules that have been electrically charged\"; using simply words: a machine used to weigh molecules. This definition is obviously correct, but the mass spectrometer is much more than an instrument. It is a complete laboratory for the investigation of molecules, clusters, and other species under the environment-free conditions of the gas phase. For this reason Mass Spectrometry (MS) is widely used today by almost all chemists and many researchers from neighbouring disciplines such as physics, medicine, or biology as a powerful analytical tool. Today the mass spectrometer is more and more present in the pharmaceutical industry, in the biological labs, in the hospitals and in many other bio-labs, while until few years ago it was present only in specialized chemical lab. This revolution starts at the end of 1980s with the introduction of two different methods able to desorbs and ionize molecules with molecular weights in a range from few hundreds daltons to millions. Until then, a few techniques, fast atom bombardment (FAB), plasma desorption (PD) and desorption chemical ionization (DCI) were able to carry out in the gas phase and to ionize molecules with a molecular weight greater than one thousand, but they all required high concentrations of sample and they did not work at all for larger molecules such as proteins or polymers. Then, in 1988, Electrospray ionization (ESI) invented by John B. Fenn and Matrix assisted laser desorption (MALDI) introduced by Franz Hillenkamp and Michael Karas appeared almost simultaneously. These desorption-ionization methods revolutionized MS and are the main forms of ionization to this day. In the beginning the two techniques were not believed robust enough, but at the end of 1990s almost all MS instruments on the market were MALDI or ESI. (literal)
Titolo
  • From micro- to femto-moles, from small to giant molecules: the route of modern Mass Spectrometry (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#inCollana
  • Seminars in organic synthesis SCI (literal)
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