http://www.cnr.it/ontology/cnr/individuo/prodotto/ID133571
Further studies on nucleopeptides with DABA-based backbone (Contributo in volume (capitolo o saggio))
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- Further studies on nucleopeptides with DABA-based backbone (Contributo in volume (capitolo o saggio)) (literal)
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- 2008-01-01T00:00:00+01:00 (literal)
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G. N.Roviello; D. Musumeci; E. M. Bucci; M. Castiglione; C. Pedone; E. Benedetti; R. Sapio; M. Valente (2008)
Further studies on nucleopeptides with DABA-based backbone
AIDIC Servizi, Milano (Italia) in IBIC 2008. Proceedings of the 1/st intern. Conference on industrial biotechnology, 2008
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- G. N.Roviello; D. Musumeci; E. M. Bucci; M. Castiglione; C. Pedone; E. Benedetti; R. Sapio; M. Valente (literal)
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- IBIC 2008. Proceedings of the 1/st intern. Conference on industrial biotechnology (literal)
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- Roviello G. N.1*, Musumeci D.2*, Bucci E. M.3, Castiglione M.1, Pedone C.1, Benedetti E.4,
Sapio R.3 and Valente M.3
1 Ist. di Biostrutture e Bioimmagini-CNR, via Mezzocannone 16, I-80134 Napoli;
2 Bionucleon srl, via D. Montesano 49, I-80131 Napoli;
3 Bionucleon srl, via Ribes 5, Colleretto Giacosa, I-10010 (TO);
4 Dip. Scienze Biologiche, Università Federico II, via Mezzocannone 16, I-80134 Napoli. (literal)
- Titolo
- Further studies on nucleopeptides with DABA-based backbone (literal)
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- Chemical Engineering Transaction (literal)
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- Gennaro Marino; Enrico Bardone; Aurelio Viglia (literal)
- Abstract
- In continuing our studies on new ODN-like molecules suitable for a wide variety of
biomedical and bioengineering applications, here we report further studies relative to a
chiral nucleopeptide with a diaminobutyric acid (DABA) backbone. In particular, in this
work we describe the synthesis of the nucleoaminoacid monomer with the D
stereochemistry, performed in analogy to our previous reports on the L-DABA derivative,
and the oligomerization using both enantiomers to form an alternate D,L-nucleopeptide.
This oligomer was studied for its ability to bind complementary DNA by CD and UV
spectroscopies. Furthermore, the new nucleopeptide showed binding evidence with a free
nucleobase probably forming a three-dimensional network based on hydrogen bonding. This
kind of structures is of particular interest for the development of new nanomaterials with
many desirable properties as well as of new ODN-analogues for biotechnological
applications. (literal)
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