The role of 18F-FDG-PET in the local/regional evaluation of women with breast cancer (Articolo in rivista)

Type
Label
  • The role of 18F-FDG-PET in the local/regional evaluation of women with breast cancer (Articolo in rivista) (literal)
Anno
  • 2002-01-01T00:00:00+01:00 (literal)
Alternative label
  • Danforth Dn. Jr., Aloj L., Carrasquillo Ja., Bacharach S.l., Chow C., Zujewski J., Whatley M., Galen B., Merino M., Neumann Rd. (2002)
    The role of 18F-FDG-PET in the local/regional evaluation of women with breast cancer
    in Breast cancer research and treatment (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Danforth Dn. Jr., Aloj L., Carrasquillo Ja., Bacharach S.l., Chow C., Zujewski J., Whatley M., Galen B., Merino M., Neumann Rd. (literal)
Pagina inizio
  • 135 (literal)
Pagina fine
  • 146 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 75 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Titolo
  • The role of 18F-FDG-PET in the local/regional evaluation of women with breast cancer (literal)
Abstract
  • PURPOSE: In women with breast cancer, knowledge of the local/regional extent of the tumor is essential for staging, treatment planning, monitoring response to therapy, and follow-up. Positron emission tomography (PET) is an important imaging test which can detect tumor at multiple sites in women with breast cancer. We compared the ability of PET to provide a comprehensive view of the local/regional extent of tumor in women with stage I, II and stage III, IV breast cancer. MATERIALS AND METHODS: Forty-six women with breast cancer underwent PET using 18F-FDG. 18FDG uptake in the breast primary tumor, associated skin, axillary and internal mammary lymph nodes, and the contralateral breast was determined qualitatively, and correlated with histologic, clinical and radiographic findings. RESULTS: Twenty-four patients were premenopausal and 22 were postmenopausal, with the following distribution according to clinical stage: stage I--2 patients, stage II--16, stage III--16, stage IV--12 patients. Among stage I, II patients, the sensitivity for detection of the primary tumor was 83.3%, and for detection of axillary lymph node metastases was 42.9%. 18FDG-PET was negative for the breast skin, contralateral breast, and internal mammary lymph nodes in all stage I, II patients, in agreement with clinical and radiographic findings. Among 28 stage III, IV patients, the sensitivity of 18FDG-PET for detection of the primary tumor was 90.5%, and for detection of axillary lymph node metastases 83.3%. Fourteen patients had clinically advanced changes in the skin, and the sensitivity of PET for detection of skin changes was 76.9%. 18FDG-PET was positive in the internal mammary lymph nodes in 25.0%, and negative in the contralateral breast in all patients with stage III, IV breast cancer. 18FDG-PET was studied in 10 patients following neoadjuvant chemotherapy, and showed a strong correlation with clinical response, and with clinical and pathological findings post-treatment at multiple local/regional sites. CONCLUSION: 18FDG-PET can provide a comprehensive image of local/regional tumor in women with breast cancer. 18FDG-PET may play a greater role in women with stage III, IV breast cancer because of increased sensitivity and the i (literal)
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