Hemodynamic determinants of exercise-induced abnormal blood pressure response in hypertrophic cardiomyopathy (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Hemodynamic determinants of exercise-induced abnormal blood pressure response in hypertrophic cardiomyopathy (Articolo in rivista) (literal)

Anno

• 2002-01-01T00:00:00+01:00 (literal)

Alternative label

• Ciampi Q., Betocchi S., Lombardi R., Manganelli F., Storto G., Losi Ma., Pezzella E., Finizio F., Cuocolo A., Chiariello M. (2002)
  Hemodynamic determinants of exercise-induced abnormal blood pressure response in hypertrophic cardiomyopathy
  in Journal of the American College of Cardiology (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Ciampi Q., Betocchi S., Lombardi R., Manganelli F., Storto G., Losi Ma., Pezzella E., Finizio F., Cuocolo A., Chiariello M. (literal)

Pagina inizio

• 1405 (literal)

Pagina fine

• 1410 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 89(12 (literal)

Rivista

• Journal of the American College of Cardiology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

• Manganelli et al ajcard (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• IBB CNR Napoli (literal)

Titolo

• Hemodynamic determinants of exercise-induced abnormal blood pressure response in hypertrophic cardiomyopathy (literal)

Abstract

• OBJECTIVES: We sought to assess the hemodynamics of exercise in patients with hypertrophic cardiomyopathy (HCM), with and without an exercise- induced abnormal blood pressure (BP) response, by ambulatory radionuclide monitoring of left ventricular (LV) function with the VEST device (Capintec Inc., Ramsey, New Jersey). BACKGROUND: Blood pressure fails to increase >20 mm Hg during exercise in about one-third of patients with HCM. This carries a high risk of sudden death. METHODS: Forty-three patients with HCM and 14 control subjects underwent maximal symptom- limited exercise on a treadmill during VEST. The VEST data were averaged for 1 min and analyzed at baseline, 3 min and peak exercise. The LV end- diastolic, end-systolic and stroke volumes, cardiac output and systemic vascular resistance were expressed as the percentage of baseline. RESULTS: Ejection fraction and stroke volume fell in patients with HCM, although they increased in control subjects (p < 0.001 and p = 0.002, respectively). Cardiac output increased significantly more in control subjects than in patients with HCM (p = 0.001). In 17 patients with HCM (39%) with an abnormal BP response, ejection fraction and stroke volume fell more (p = 0.032 and p = 0.009, respectively) and cardiac output increased less (p = 0.001) than they did in patients with HCM with a normal BP response. Systemic vascular resistance decreased similarly in patients with HCM, irrespective of the BP response. CONCLUSIONS: In patients with HCM with and without an abnormal BP response, abnormal hemodynamic adaptation to exercise was qualitatively similar but quantitatively different. An abnormal BP response was associated with exercise-induced LV systolic dysfunction. This causes hemodynamic instability, associated with a high risk of sudden cardiac death. (literal)

Prodotto di

• Institute of biostructure and bioimaging (IBB) (Istituto)

Autore CNR

• GIOVANNI STORTO (Unità di personale interno)

Incoming links:

Prodotto

• Institute of biostructure and bioimaging (IBB) (Istituto)

Autore CNR di

• GIOVANNI STORTO (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of the American College of Cardiology (Rivista)