http://www.cnr.it/ontology/cnr/individuo/prodotto/ID13340
Cationic liposomes as delivery systems for double-stranded PNA-DNA chimeras exhibiting decoy activity against NF-kb transcription factors (Articolo in rivista)
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- Label
- Cationic liposomes as delivery systems for double-stranded PNA-DNA chimeras exhibiting decoy activity against NF-kb transcription factors (Articolo in rivista) (literal)
- Anno
- 2002-01-01T00:00:00+01:00 (literal)
- Alternative label
Borgatti M., Breda L., Cortesi R., Nastruzzi C., Romanelli A., Saviano M., Bianchi N., Mischiati C., Pedone C., Gambari R. (2002)
Cationic liposomes as delivery systems for double-stranded PNA-DNA chimeras exhibiting decoy activity against NF-kb transcription factors
in Biochemical pharmacology
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- Borgatti M., Breda L., Cortesi R., Nastruzzi C., Romanelli A., Saviano M., Bianchi N., Mischiati C., Pedone C., Gambari R. (literal)
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- ISI Web of Science (WOS) (literal)
- Titolo
- Cationic liposomes as delivery systems for double-stranded PNA-DNA chimeras exhibiting decoy activity against NF-kb transcription factors (literal)
- Abstract
- Peptide nucleic acids (PNAs) have been recently proposed as useful mols. in
pharmacogenetic therapy, esp. due to the fact that they show a very high
stability with respect to DNA and RNA. However, PNAs are not efficient
decoy mols., are characterized by negligible cell internalization and low
soly. and are not suitable to be delivered by liposomes. With respect to
the biol. activity of PNA-based mols., PDP deserve great consideration, due
to the fact that they exhibit high levels of soly., and are expected to be
resistant to proteinases and exonucleases. In this manuscript we detd.
whether double-stranded mols. based on PNA-DNA chimeras contg. NF-kB
binding sites, exhibit decoy activity against NF-kB transcription factors.
In addn., we detd. whether they can be complexed by cationic liposomes.
The results obtained demonstrated that hybrids based on PNA-DNA chimeras
are powerful decoy mols. against NF-kB p52 transcription factor. In addn.,
we found that cationic liposomes can be proposed for in vitro delivery to
target cells of these decoy mols. The results presented in this paper are
thus of practical importance, since the simplicity and the versatility of
the cationic liposome technol. have made cationic liposomes useful nonviral
gene delivery systems for human gene therapy. (literal)
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