From Allergen Back To Antigen: A Rational Approach To New Forms Of Immunotherapy (Contributo in volume (capitolo o saggio))

Type
Label
  • From Allergen Back To Antigen: A Rational Approach To New Forms Of Immunotherapy (Contributo in volume (capitolo o saggio)) (literal)
Anno
  • 2007-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1142/9789812779458_0019 (literal)
Alternative label
  • Colombo P 1); Trapani A1);Geraci D1); Golino M2); Gianguzza F 2); Bonura A 1); (2007)
    From Allergen Back To Antigen: A Rational Approach To New Forms Of Immunotherapy
    in Modelling and Simulation in Science: 6th International Workshop on Data Analysis in Astronomy, Erice, Italy, 15-22 April 2007, 2007
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Colombo P 1); Trapani A1);Geraci D1); Golino M2); Gianguzza F 2); Bonura A 1); (literal)
Pagina inizio
  • 154 (literal)
Pagina fine
  • 157 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#citta
  • Erice, 15-22 Aprile 2007 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#titoloVolume
  • Modelling and Simulation in Science: 6th International Workshop on Data Analysis in Astronomy, Erice, Italy, 15-22 April 2007 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 4 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1)Istituto di biomedicina e di immunologia molecolare \"Alberto Monroy\", 2)Universit√† degli Studi di Palermo, (literal)
Titolo
  • From Allergen Back To Antigen: A Rational Approach To New Forms Of Immunotherapy (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#inCollana
  • In Science Proceedings of the 6th International Workshop on Data Analysis in Astronomy. (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#isbn
  • 978-981-277-944-1 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#curatoriVolume
  • Vito Di Gesu, L. Scarsi (literal)
Abstract
  • Mapping an epitope on a protein by gene fragmentation and/or point mutations is often expensive and time consuming. Analysis of a 3D model can be utilized to detect the amino acids residues which are exposed to the solvent surface and thus represent potential epitope residues. Parj1 and Parj2 are the two major allergens of the Parietaria judaica pollen belonging to the Lipid Transfer Protein family. Using their three-dimensional structures as a guide, a head to tail dimer expressing disulphide bond variants of the major allergens was generated by means of DNA recombinant technology. The hybrid was expressed in E.coli and its immunological activity studied in vivo and in vitro. Our results demonstrate that a hybrid polypeptide expressing disulphide bond variants of the major allergens of the Parietaria pollen displayed reduced allergenicity and enhanced T cell reactivity for induction of protective antibodies able to block human IgE induced during the natural course of sensitization against the Parietaria pollen. (literal)
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