Post-transplant donor-specific antibody production and graft outcome in kidney transplantation: results of 16-year monitoring by flow cytometry. (Contributo in volume (capitolo o saggio))

Type
Label
  • Post-transplant donor-specific antibody production and graft outcome in kidney transplantation: results of 16-year monitoring by flow cytometry. (Contributo in volume (capitolo o saggio)) (literal)
Anno
  • 2007-01-01T00:00:00+01:00 (literal)
Alternative label
  • Antonina Piazza1; Elvira Poggi1; Giuseppina Ozzella1; Laura Borrelli1; Alessandra Scornajenghi1; Giuseppe Iaria2; Giuseppe Tisone2; Domenico Adorno1 (2007)
    Post-transplant donor-specific antibody production and graft outcome in kidney transplantation: results of 16-year monitoring by flow cytometry.
    in Clinical Transplants 2006, 2007
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Antonina Piazza1; Elvira Poggi1; Giuseppina Ozzella1; Laura Borrelli1; Alessandra Scornajenghi1; Giuseppe Iaria2; Giuseppe Tisone2; Domenico Adorno1 (literal)
Pagina inizio
  • 323 (literal)
Pagina fine
  • 336 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#citta
  • Los Angeles, California (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#titoloVolume
  • Clinical Transplants 2006 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#volumeInCollana
  • 2006 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 14 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1 National College of Researches, Institute of Organ Transplantation, Rome, Italy; 2 Department of Surgery, Tor Vergata University, Rome, Italy (literal)
Titolo
  • Post-transplant donor-specific antibody production and graft outcome in kidney transplantation: results of 16-year monitoring by flow cytometry. (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#inCollana
  • Clinical Transplant 2006 Cap.36: 193-206 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#isbn
  • 978-1-880318-15-7 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autoriVolume
  • Paul I. Terasaki (literal)
Abstract
  • The use of modern immunosuppressive therapy in kidney transplantation has reduced the occurrence of acute rejection and improved short-term graft survival (1) but has been ineffective to prevent chronic allograft dysfunction, which leads to graft failure (2). Many studies have analyzed the posttransplant production of donor-specific alloantibodies. These have been associated with acute and chronic rejection and with reduced graft survival (3-9). Moreover, antibody production can precede any clinical manifestations of graft dysfunction (6, 8, 10). Therefore, the detection and characterization of donor-specific antibodies has become an important task for histocompatibility laboratories. In our laboratory, monitoring for the development of donor-specific antibodies (DSA) in patients receiving a kidney transplant began in 1990. We first used flow cytometric cross-match and then FlowPRATM beads (One Lambda, Canoga Park, CA, USA) which consist of microbeads coated with purified or recombinant HLA class I and II antigens. Here we report the results of 16-year monitoring of posttransplant DSA development in patients who received a cadaveric donor kidney transplant. We also analyze the impact of DSA production on graft outcome and survival. (literal)
Prodotto di
Autore CNR

Incoming links:


Autore CNR di
Prodotto
data.CNR.it