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A chemical shift imaging study on regional metabolite distribution in a CADASIL family (Articolo in rivista)

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A chemical shift imaging study on regional metabolite distribution in a CADASIL family (Articolo in rivista) (literal)

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Macri, MA; Colonnese, C; Garreffa, G; Fattapposta, F; Restuccia, R; Bianco, F; Labruna, L; Maraviglia, B (2006)
A chemical shift imaging study on regional metabolite distribution in a CADASIL family
in Magnetic resonance imaging
(literal)

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Macri, MA; Colonnese, C; Garreffa, G; Fattapposta, F; Restuccia, R; Bianco, F; Labruna, L; Maraviglia, B (literal)

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Museo Stor Fis, I-00184 Rome, Italy; Ctr Ric Enrico Fermi, I-00184 Rome, Italy; Univ Roma La Sapienza, Dipartimento Med Sperimentale & Patol, I-00185 Rome, Italy; SOFT, Ctr Ric & Sviluppo, I-00185 Rome, Italy; Ist Neurol Mediterraneo, I-86077 Pozzilli, Italy; Univ Roma La Sapienza, Dept Neurol & ORL, I-00185 Rome, Italy; Ist Ricovero & Cura Carattere San Raffaele Pisana, I-00163 Rome, Italy; Univ Naples Federico II, Dipartimento Neurosci, I-80131 Naples, Italy; Univ Roma La Sapienza, Dipartimento Fis, I-00185 Rome, Italy (literal)

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A chemical shift imaging study on regional metabolite distribution in a CADASIL family (literal)

Abstract

A chemical shift imaging (CSI) study was performed to directly assess relative concentrations of N-acetylaspartate (NAA), Cho and Cr metabolites in normal- and abnormal-appearing brain tissue of asymptomatic and symptomatic members of a single family with a neuropathologic, genetic and electrophysiological confirmed diagnosis of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. The aim of the investigation was to evaluate clinical findings and metabolite abnormalities as early appearance of axonal injury in this syndrome. The main findings related statistically significant decreases in the mean metabolite ratios for NAA/Cr, NAA/Cho and Cho/Cr in the anterior parts in comparison with the posterior parts of the centrum semiovale in symptomatic and asymptomatic patients. The effect was considerably greater in the symptomatic patients, indicating a strong correlation between CSI and pathology results. No differences were found between the two areas in the control group. Although lactate signals were hardly detectable in individual spectra, there was a trend toward increased Lac/Cr values in the anterior parts with respect to the posterior parts in the patient group, with the effect particularly evident in the asymptomatic subjects with the gene mutation. (c) 2006 Elsevier Inc. All rights reserved. (literal)

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