Effect of duloxetine in conditioned and unconditioned behavioural models of anxiety (Abstract/Poster in atti di convegno)

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  • Effect of duloxetine in conditioned and unconditioned behavioural models of anxiety (Abstract/Poster in atti di convegno) (literal)
Anno
  • 2008-01-01T00:00:00+01:00 (literal)
Alternative label
  • Casti P., Marcello S., Pisu C., Pira L.i & Pani L.. (2008)
    Effect of duloxetine in conditioned and unconditioned behavioural models of anxiety
    in 6° Forum of European Neuroscience, Ginevra
    (literal)
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  • Casti P., Marcello S., Pisu C., Pira L.i & Pani L.. (literal)
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  • Duloxetine is a potent inhibitor of both serotonin and norepinephrine reuptake systems used in the treatment of major depressive disorder. Some clinical trials indicated that duloxetine improved anxiety symptoms in patients affected by generalized anxiety disorder. Furthermore, the potential anxiolytic properties of duloxetine were also supported by few pre-clinical studies. The aim of the present work was to further investigate the effect of chronic administration of duloxetine in some preclinical paradigms of anxiety: fear conditioning, Vogel’s conflict test, novelty suppressed-feeding and elevated plus maze. In the fear conditioning test, mice were treated by oral gaveage (o.g.) with duloxetine (15mg/kg), or citalopram (used as reference anxiolytic drug; 15 mg/kg) or vehicle twice a day for three weeks. In the other behavioural tests, the effect of duloxetine chronic treatment (10 mg/kg, o.g.) was compared to that induced by acute administration of diazepam (1 mg/kg, intaperitoneal). The groups of duloxetine and vehicle-treated mice, after 24-hours of wash out, received vehicle and diazepam injection ,respectively, and 30 minutes later behavioural tests were carried out. Our results indicate that, in fear conditioning paradigm, duloxetine and citalopram decreased freezing behaviour to auditory cue but duloxetine increased fear behaviour to context. Both duloxetine and diazepam augmented punished responding in the Vogel’s conflict test and reduced hyponeophagia, but diazepam decreased latency to eat in familiar environment. Finally, duloxetine reduced entries in open arms, suggesting a weak anxiogenic-like effect, and diazepam increased the ratio of time spent in open arms with respect to closed arms. Taken together, these results indicate that the chronic administration of duloxetine induces anxiolytic-like effects in different animal models of anxiety, except in the elevated plus maze, supporting the role of duloxetine as anxiolytic drug. (literal)
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  • Pharmaness Scarl, Ed.5, Loc.Piscinamanna; 09010 Pula (CA), Italy. (literal)
Titolo
  • Effect of duloxetine in conditioned and unconditioned behavioural models of anxiety (literal)
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