http://www.cnr.it/ontology/cnr/individuo/prodotto/ID12880

Angiotensin Converting Enzyme (ACE) Inhibitory Peptides: Production and Implementation of Functional Food (Articolo in rivista)

Type

Prodotto della ricerca (Classe)
Articolo in rivista (Classe)

Label

Angiotensin Converting Enzyme (ACE) Inhibitory Peptides: Production and Implementation of Functional Food (Articolo in rivista) (literal)

Anno

2009-01-01T00:00:00+01:00 (literal)

Alternative label

De Leo F. , S. Panarese, R. Gallerani, and L. R. Ceci (2009)
Angiotensin Converting Enzyme (ACE) Inhibitory Peptides: Production and Implementation of Functional Food
in Current pharmaceutical design (Print); Bentham Science Publishers Ltd., Sharjah (Emirati Arabi Uniti)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

De Leo F. , S. Panarese, R. Gallerani, and L. R. Ceci (literal)

Pagina inizio

3622 (literal)

Pagina fine

3643 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

15 (literal)

Rivista

Current pharmaceutical design (Rivista)

Note

ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

1Institute for Biomembranes and Bioenergetics, CNR, Via Amendola 165/A, 70126 Bari, Italy, 2Department of Biochemistry and Molecular Biology \"Ernesto Quagliariello\", University of Bari, Via Amendola 165/A, 70126 Bari, Italy (literal)

Titolo

Angiotensin Converting Enzyme (ACE) Inhibitory Peptides: Production and Implementation of Functional Food (literal)

Abstract

In recent decades, the most successful strategy for controlling blood pressure has been inhibition of the angiotensin-converting enzyme (ACE). ACE inhibitors of chemical synthesis (captopril, enalapril, ramipril and trandolapril) have been widely used clinically to reduce mortality in patients with heart failure, and in patients with recent myocardial infarction and heart failure or marked left ventricular dysfunction. In addition to preventive and therapeutic drugs, increased attention has been paid to identifying dietary compounds that may contribute to cardiovascular treatment and prevention. ACE inhibitory peptides, derived from a multitude of plant and animal proteins such as milk, soy or fish, represent sources of health-enhancing components. These ACE inhibitory peptides can be enzymatically released from precursor proteins in vitro and in vivo, respectively during food processing and gastrointestinal digestion. They have shown the ability to lower blood pressure by limiting the vasoconstrictory effects of Angiotensin II and potentiating the vasodilatory effects of Bradykinin. By using specific procedures they may be generated in or incorporated into functional foods for the development of 'natural' beneficial health products. Several products containing peptides with ACE inhibitory properties are currently on the market or in development. This review focuses on the use, application and future perspective of bioactive peptides with properties relevant to cardiovascular health. (literal)

Editore