Peroxisomes as novel players in cell calcium homeostasis (Articolo in rivista)

Type
Label
  • Peroxisomes as novel players in cell calcium homeostasis (Articolo in rivista) (literal)
Anno
  • 2008-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1074/jbc.M800648200 (literal)
Alternative label
  • Lasorsa FM, Pinton P, Palmieri L, Scarcia P, Rottensteiner H, Rizzuto R, Palmieri F (2008)
    Peroxisomes as novel players in cell calcium homeostasis
    in The Journal of biological chemistry (Print); American Society Of Biochemistry And Molecular Biology Inc. (ASBMB), Rockville (Stati Uniti d'America)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Lasorsa FM, Pinton P, Palmieri L, Scarcia P, Rottensteiner H, Rizzuto R, Palmieri F (literal)
Pagina inizio
  • 15300 (literal)
Pagina fine
  • 15308 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 283 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 22 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Laboratory of Biochemistry and Molecular Biology, Department of Pharmaco-Biology, University of Bari, Via Orabona 4, 70125 Bari, Italy National Research Council Institute of Biomembranes and Bioenergetics (IBBE), via Amendola 165/A, 70126, Bari, Italy (literal)
Titolo
  • Peroxisomes as novel players in cell calcium homeostasis (literal)
Abstract
  • Ca2+ concentration in peroxisomal matrix ([Ca2+]perox) has been monitored dynamically in mammalian cells expressing variants of Ca2+-sensitive aequorin specifically targeted to peroxisomes. Upon stimulation with agonists that induce Ca2+ release from intracellular stores, peroxisomes transiently take up Ca2+ reaching peak values in the lumen as high as 50-100 muM, depending on cell types. Also in resting cells, peroxisomes sustain a Ca2+ gradient, [Ca2+]perox being about 20-fold higher than [Ca2+] in the cytosol ([Ca2+]cyt). The properties of Ca2+ traffic across the peroxisomal membrane are different from those reported for other subcellular organelles. The sensitivity of peroxisomal Ca2+ uptake to agents dissipating H+ and Na+ gradients unravels the existence of a complex bioenergetic framework including V-ATPase, Ca2+/H+ and Ca2+/Na+ activities whose components are yet to be identified at a molecular level. The different [Ca2+]perox of resting and stimulated cells suggest that Ca2+ could play an important role in the regulation of peroxisomal metabolism (literal)
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