Different sources of reactive oxygen species contribute to low-potassium induced apoptosis in cerebellar granule cells (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Different sources of reactive oxygen species contribute to low-potassium induced apoptosis in cerebellar granule cells (Articolo in rivista) (literal)

Anno

• 2008-01-01T00:00:00+01:00 (literal)

Alternative label

• Bobba A; Atlante A; Petragallo V; Marra E (2008)
  Different sources of reactive oxygen species contribute to low-potassium induced apoptosis in cerebellar granule cells
  in International Journal of Molecular Medicine
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Bobba A; Atlante A; Petragallo V; Marra E (literal)

Pagina inizio

• 737 (literal)

Pagina fine

• 745 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 21 (literal)

Rivista

• International Journal of Molecular Medicine (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Istituto di Biomembrane e Bioenergetica, CNR, Via Amendola 165/A, 70126 Bari; Istituto di Neurobiologia e Medicina Molecolare, CNR, Viale Marx 15, 00137 Roma, Italy. (literal)

Titolo

• Different sources of reactive oxygen species contribute to low-potassium induced apoptosis in cerebellar granule cells (literal)

Abstract

• An early increase in ROS production is characteristic of cerebellar granule cells undergoing apoptosis in the presence of 5 mM KCl. However the source/es of this increase has/have never been dealt with in detail. In particular whether there is a single enzymatic source or the increase in ROS production is the consequence of the involvement of different enzymes has not been studied in depth. Different enzymatic pathways may indeed contribute to upregulate intracellular ROS production either directly or via side-chain reactions and a number of candidate enzymes are known to be involved in the apoptotic process in various cell types. The aim of this study was to identify the cellular source/es of the ROS generated by CGCs undergoing apoptosis by low K+. A panel of specific inhibitors against phospholipase, cytochromes P450, cyclooxygenase, lipoxygenase, xanthine oxidase, ribonucleotide reductase and NADPH oxidase were used. We provide evidence that no a single source of ROS can be identified in apoptotic CGCs but the ROS generated through the arachidonic acid (AA) pathways, mainly via lipoxygenase activities, seems to be the most prominent. (literal)

Prodotto di

• Istituto di biomembrane e bioenergetica (IBBE) (Istituto)
• Interrelazione nucleo/citoplasma/mitocondri nell'omeostasi cellulare. (SV.P15.003.001) (Modulo)

Autore CNR

• ANTONELLA BOBBA (Persona)
• VITO ANTONIO PETRAGALLO (Persona)
• ERSILIA MARRA (Unità di personale interno)
• ANNA ATLANTE (Unità di personale interno)

Insieme di parole chiave

• Keywords of "Different sources of reactive oxygen species contribute to low-potassium induced apoptosis in cerebellar granule cells" (Insieme di parole chiave)

Incoming links:

Prodotto

• Istituto di biomembrane e bioenergetica (IBBE) (Istituto)
• Interrelazione nucleo/citoplasma/mitocondri nell'omeostasi cellulare. (SV.P15.003.001) (Modulo)

Autore CNR di

• ANTONELLA BOBBA (Persona)
• VITO ANTONIO PETRAGALLO (Persona)
• ERSILIA MARRA (Unità di personale interno)
• ANNA ATLANTE (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• International Journal of Molecular Medicine (Rivista)

Insieme di parole chiave di

• Keywords of "Different sources of reactive oxygen species contribute to low-potassium induced apoptosis in cerebellar granule cells" (Insieme di parole chiave)