Porin and cytochrome oxidase containing contact sites involved in the oxidation of cytosolic NADH (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Porin and cytochrome oxidase containing contact sites involved in the oxidation of cytosolic NADH (Articolo in rivista) (literal)

Anno

• 2005-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.abb.2004.12.029 (literal)

Alternative label

• La Piana G; Marzulli D; Gorgoglione V; Lofrumento NE (2005)
  Porin and cytochrome oxidase containing contact sites involved in the oxidation of cytosolic NADH
  in Archives of biochemistry and biophysics (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• La Piana G; Marzulli D; Gorgoglione V; Lofrumento NE (literal)

Pagina inizio

• 91 (literal)

Pagina fine

• 100 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 436 (literal)

Rivista

• Archives of biochemistry and biophysics (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 10 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 1 (literal)

Note

• PubMe (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Department of Biochemistry and Molecular Biology, University of Bari, via Orabona 4, 70126 Bari, Italy. (literal)

Titolo

• Porin and cytochrome oxidase containing contact sites involved in the oxidation of cytosolic NADH (literal)

Abstract

• Cytochrome c (cyto-c) added to isolated mitochondria promotes the oxidation of extra-mitochondrial NADH and the reduction of molecular oxygen associated to the generation of an electrochemical membrane potential available for ATP synthesis. The electron transport pathway activated by exogenous cyto-c molecules is completely distinct from the one catalyzed by the respiratory chain. Dextran sulfate (500 kDa), known to interact with porin (the voltage-dependent anion channel), other than to inhibit the release of ATP synthesized inside the mitochondria, greatly decreases the activity of exogenous NADH/cyto-c system of intact mitochondria but has no effect on the reconstituted system made of mitoplasts and external membrane preparations. The results obtained are consistent with the existence of specific contact sites containing cytochrome oxidase and porin, as components of the inner and the outer membrane respectively, involved in the oxidation of cytosolic NADH. The proposal is put forward that the bi-trans-membrane electron transport chain activated by cytosolic cyto-c becomes, in physio-pathological conditions: (i) functional in removing the excess of cytosolic NADH; (ii) essential for cell survival in the presence of an impairment of the first three respiratory complexes; and (iii) an additional source of energy at the beginning of apoptosis. (literal)

Prodotto di

• Trasportatori mitocondriali: struttura e meccanismi funzionali (SV.P14.007.001) (Modulo)
• Istituto di biomembrane e bioenergetica (IBBE) (Istituto)

Autore CNR

• DOMENICO MARZULLI (Persona)

Insieme di parole chiave

• Keywords of "Porin and cytochrome oxidase containing contact sites involved in the oxidation of cytosolic NADH" (Insieme di parole chiave)

Incoming links:

Prodotto

• Istituto di biomembrane e bioenergetica (IBBE) (Istituto)
• Trasportatori mitocondriali: struttura e meccanismi funzionali (SV.P14.007.001) (Modulo)

Autore CNR di

• DOMENICO MARZULLI (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Archives of biochemistry and biophysics (Rivista)

Insieme di parole chiave di

• Keywords of "Porin and cytochrome oxidase containing contact sites involved in the oxidation of cytosolic NADH" (Insieme di parole chiave)