Apoptosis and cytochrome c release in cerebellar granule cells. (Articolo in rivista)

Type
Label
  • Apoptosis and cytochrome c release in cerebellar granule cells. (Articolo in rivista) (literal)
Anno
  • 2004-01-01T00:00:00+01:00 (literal)
Alternative label
  • Bobba A; Atlante A; de Bari L; Passarella S; Marra E (2004)
    Apoptosis and cytochrome c release in cerebellar granule cells.
    in In vivo (Athens)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Bobba A; Atlante A; de Bari L; Passarella S; Marra E (literal)
Pagina inizio
  • 335 (literal)
Pagina fine
  • 344 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 18 (literal)
Rivista
Note
  • Scopu (literal)
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Istituto di Biomembrane e Bioenergetica, CNR, Via G. Amendola, 165/A - 70126 Bari; Dipartimento di Scienze Animali, Vegetali e dell'Ambiente, Università del Molise, Via De Sanctis, 86100 Campobasso, Italy (literal)
Titolo
  • Apoptosis and cytochrome c release in cerebellar granule cells. (literal)
Abstract
  • In the light of both the major role played by released cytochrome c in apoptosis of a variety of cells and the availability of cerebellar granule cells as a model system to investigate apoptosis as a function of time from induction to cell death, we review data aimed at elucidating the events dealing with cytochrome c release from mitochondria as well as its role outside mitochondria. We report cytochrome c release in the apoptosis time course as dependent on the function of both the antioxidant and proteolytic systems. We show that, beside the role played by cytochrome c in participating in apoptosome formation and in triggering the caspase cascade, at least in cerebellar granule cells, released cytochrome c can maintain its ability to work as an electron carrier, being a scavenger of reactive oxygen species and an electron donor to cytochrome oxidase, thus driving the ATP synthesis. (literal)
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