http://www.cnr.it/ontology/cnr/individuo/prodotto/ID12533
Differential expression of specific microRNA and their targets in acute myeloid leukemia (Articolo in rivista)
- Type
- Label
- Differential expression of specific microRNA and their targets in acute myeloid leukemia (Articolo in rivista) (literal)
- Anno
- 2010-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1002/ajh.21667 (literal)
- Alternative label
Cammarata G, Augugliaro L, Salemi D, Agueli C, La Rosa M, Dagnino L, Civiletto G, Messana F, Marfia A, Bica MG, Cascio L, Floridia PM, Mineo AM, Russo M, Fabbiano F, Santoro A. (2010)
Differential expression of specific microRNA and their targets in acute myeloid leukemia
in American journal of hematology (Print)
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Cammarata G, Augugliaro L, Salemi D, Agueli C, La Rosa M, Dagnino L, Civiletto G, Messana F, Marfia A, Bica MG, Cascio L, Floridia PM, Mineo AM, Russo M, Fabbiano F, Santoro A. (literal)
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- Divisione di Ematologia con UTMO, A.O. Ospedali Riuniti Villa Sofia-Cervello, Palermo Italy
Consiglio Nazionale delle Ricerche, Istituto di Biomedicina e Immunologia Molecolare \"Alberto Monroy\", Palermo Italy
Dipartimento di Scienze Statistiche e Matematiche \"Silvio Vianelli,\" Università di Palermo, Palermo, Italy
Divisione di Ematologia, P.O. \"S.Vincenzo\", Taormina (ME), Italy (literal)
- Titolo
- Differential expression of specific microRNA and their targets in acute myeloid leukemia (literal)
- Abstract
- Acute myeloid leukemia (AML) the most common acute leukemia in adults is characterized by various cytogenetic
and molecular abnormalities. However, the genetic etiology of the disease is not yet fully understood.
MicroRNAs (miRNA) are small noncoding RNAs which regulate the expression of target mRNAs both
at transcriptional and translational level. In recent years, miRNAs have been identified as a novel mechanism
in gene regulation, which show variable expression during myeloid differentiation. We studied miRNA
expression of leukemic blasts of 29 cases of newly diagnosed and genetically defined AML using quantitative
reverse transcription polymerase chain reaction (RT-PCR) for 365 human miRNA. We showed that
miRNA expression profiling reveals distinctive miRNA signatures that correlate with cytogenetic and molecular
subtypes of AML. Specific miRNAs with consolidated role on cell proliferation and differentiation such
as miR-155, miR-221, let-7, miR-126 and miR-196b appear to be associated with particular subtypes. We
observed a significant differentially expressed miRNA profile that characterizes two subgroups of AML with
different mechanism of leukemogenesis: core binding factor (CBF) and cytogenetically normal AML with
mutations in the genes of NPM1 and FLT3-ITD. We demonstrated, for the first time, the inverse correlation
of expression levels between miRNA and their targets in specific AML genetic groups. We suggest that
miRNA deregulation may act as complementary hit in the multisteps mechanism of leukemogenesis offering
new therapeutic strategies. (literal)
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