http://www.cnr.it/ontology/cnr/individuo/prodotto/ID12439
Ferulic acid inhibits oxidative stress and cell death induced by Ab oligomers: Improved delivery by solid lipid nanoparticles. (Articolo in rivista)
- Type
- Label
- Ferulic acid inhibits oxidative stress and cell death induced by Ab oligomers: Improved delivery by solid lipid nanoparticles. (Articolo in rivista) (literal)
- Anno
- 2009-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1080/10715760903214454 (literal)
- Alternative label
Picone P.; Bondi M.L., Montana G.; Bruno A.; Pitarresi G.; Giammona G.; Di Carlo M. (2009)
Ferulic acid inhibits oxidative stress and cell death induced by Ab oligomers: Improved delivery by solid lipid nanoparticles.
in Free radical research; Informa Healthcare, New York (Stati Uniti d'America)
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Picone P.; Bondi M.L., Montana G.; Bruno A.; Pitarresi G.; Giammona G.; Di Carlo M. (literal)
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- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
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- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note
- PubMed PMID: 19863373. (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Titolo
- Ferulic acid inhibits oxidative stress and cell death induced by Ab oligomers: Improved delivery by solid lipid nanoparticles. (literal)
- Abstract
- Oxidative stress and dysfunctional mitochondria are among the earliest events in AD, triggering neurodegeneration. The use
of natural antioxidants could be a neuroprotective strategy for blocking cell death. Here, the antioxidant action of ferulic acid
(FA) on different paths leading to degeneration of recombinant b-amyloid peptide (rAb42) treated cells was investigated.
Further, to improve its delivery, a novel drug delivery system (DDS) was used. Solid lipid nanoparticles (SLNs), empty or
containing ferulic acid (FA-SNL), were developed as DDS. The resulting particles had small colloidal size and highly
negative surface charge in water. Using neuroblastoma cells and rAb42 oligomers, it was demonstrated that free and SLNsloaded
FA recover cell viability. FA treatment, in particular if loaded into SLNs, decreased ROS generation, restored
mitochondrial membrane potential (Dcm) and reduced cytochrome c release and intrinsic pathway apoptosis activation.
Further, FA modulated the expression of Peroxiredoxin, an anti-oxidative protein, and attenuated phosphorylation of
ERK1/2 activated by Ab oligomers. (literal)
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