http://www.cnr.it/ontology/cnr/individuo/prodotto/ID12425
Beta amyloid peptide: from different aggregation forms to the activation of different biochemical pathways (Articolo in rivista)
- Type
- Label
- Beta amyloid peptide: from different aggregation forms to the activation of different biochemical pathways (Articolo in rivista) (literal)
- Anno
- 2010-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1007/s00249-009-0439-8 (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note
- La rivista corretta è: EUROPEAN BIOPHYSICS (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Titolo
- Beta amyloid peptide: from different aggregation forms to the activation of different biochemical pathways (literal)
- Abstract
- Amyloid beta peptide (Ab) is the major component
of amyloid plaques in the brain of individuals aVected
by Alzheimer's disease (AD). The formation of the plaques
is due to an overproduction of Ab by APP processing, its
precursor, and to its ability to convert under specific conditions
from its soluble form into highly ordered fibrillar
aggregates. Although neuronal degeneration occurs near
the amyloid plaques, some studies have suggested that
intermediates such as protofibrils or simple oligomers are
also involved in AD pathogenesis and even appear to be the
more dangerous species in the onset of the pathology. Further,
toxic properties of aggregates of different size have
been investigated and the obtained results support the
hypothesis that different aggregate sizes can induce different
degeneration pathways. In the present review some of
the knowledge about the biochemical routes of Ab processing
and production and the relationship among Ab and oxidative
stress, metal homeostasis, inXammatory process, and
cell death are summarized. Moreover, current strategies
addressing both Wbrillogenesis process and different Ab
altered biochemical pathways utilized for therapies are
described. (literal)
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- Autore CNR
- Insieme di parole chiave
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