http://www.cnr.it/ontology/cnr/individuo/prodotto/ID12394
Manganese effects on haematopoietic cells and circulating coelomocytes of Asterias rubens (Linnaeus). (Articolo in rivista)
- Type
- Label
- Manganese effects on haematopoietic cells and circulating coelomocytes of Asterias rubens (Linnaeus). (Articolo in rivista) (literal)
- Anno
- 2008-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1016/j.aquatox.2008.05.016 (literal)
- Alternative label
Oweson C, Sköld H, Pinsino A, Matranga V, Hernroth B (2008)
Manganese effects on haematopoietic cells and circulating coelomocytes of Asterias rubens (Linnaeus).
in Aquatic toxicology
(literal)
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- Oweson C, Sköld H, Pinsino A, Matranga V, Hernroth B (literal)
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- Note
- ISI Web of Science (WOS) (literal)
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- Department of Marine Ecology, Göteborg University, Kristineberg 566, 45034 Fiskebäckskil, Sweden; Istituto di Biomedicina e Immunologia Molecolare \"A. Monroy\", Via Ugo La Malfa 153, 90146 Palermo, Italy; The Royal Swedish Academy of Sciences, Kristineberg 566, 45034 Fiskebäckskil, Sweden (literal)
- Titolo
- Manganese effects on haematopoietic cells and circulating coelomocytes of Asterias rubens (Linnaeus). (literal)
- Abstract
- Manganese (Mn) is a naturally abundant metal in marine sediments where it mainly occurs as MnO2.
During hypoxic conditions it is converted into a bioavailable state, Mn2+, and can reach levels that previously
have shown effects on immune competent cells of the crustacean, Nephrops norvegicus. Here
we investigated if Mn also affects circulating coelomocytes and their renewal in the common sea star,
Asterias rubens, when exposed to concentrations of Mn that can be found in nature. When the sea stars
were exposed to Mn it accumulated in the coelomic fluid and the number of circulating coelomocytes,
in contrast to what was recorded in Nephrops, increased significantly. By using the substitute nucleotide,
5-bromo-2?-deoxyuridine, BrdU, for tracing cell division and by recording mitotic index by nuclei staining,
we found that Mn induced proliferation of cells from a putative haematopoietic tissue, the coelomic
epithelium. In addition, the haematopoietic tissue and coelomocytes showed stress response in terms of
changes in HSP70 levels and protein carbonyls, as judged by immunohistochemistry andWestern blotting.
Measurement of dehydrogenase activity, using MTS/PMS, revealed that Mn showed cytotoxic properties.
We also found that the phagocytotic capacity of coelomocytes was significantly inhibited by Mn. It was
concluded that the exposure of A. rubens to Mn induced renewal of coelomocytes and impaired their
immune response. (literal)
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