http://www.cnr.it/ontology/cnr/individuo/prodotto/ID12309
Sex hormones and risk of liver tumor. (Articolo in rivista)
- Type
- Label
- Sex hormones and risk of liver tumor. (Articolo in rivista) (literal)
- Anno
- 2006-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1196/annals.1386.044 (literal)
- Alternative label
Giannitrapani L, Soresi M, La Spada E, Cervello M, D'Alessandro N, Montalto G. (2006)
Sex hormones and risk of liver tumor.
in Annals of the New York Academy of Sciences
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Giannitrapani L, Soresi M, La Spada E, Cervello M, D'Alessandro N, Montalto G. (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- IBIM- CNR - Palermo, Italy
Università di Palermo, Palermo, Italy (literal)
- Titolo
- Sex hormones and risk of liver tumor. (literal)
- Abstract
- The liver is morphologically and functionally modulated by
sex hormones. Long-term use of oral contraceptives (OCs) and anabolic
androgenic steroids (AASs) can induce both benign (hemangioma, adenoma,
and focal nodular hyperplasia [FNH]) and malignant (hepatocellular
carcinoma [HCC]) hepatocellular tumors. Hepatic adenomas
(HAs) are rare, benign neoplasms usually occurring in young women,
the development and the complications of which have been related to the
strength of OCs and the duration of their use. HA incidence has fallen
since the introduction of pills containing smaller amounts of estrogens.
FNH is a benign lesion, most commonly seen in young women, which is
thought to represent a local hyperplastic response of hepatocytes to a vascular
abnormality. Because of the female predominance and the young
age at onset, a role of female hormones has been suggested. Furthermore,
a large proportion of women with FNH (50-75%) are OC users. Liver
hemangiomas (LHs) are the most common benign liver tumors and are
seen more commonly in young adult females. The female predilection
and clinical observations of LH growth under conditions of estrogenic
exposure suggest a possible role for estrogen in the pathogenesis of LHs.
HCC has become one of the most widespread tumors in the world in
recent years, representing the sixth leading cancer and the third most
common cause of death from cancer. Apart from liver cirrhosis, numerous
other factors responsible for its onset have been proposed: hepatitis
infections from virus B (HBV) and C (HCV), alcohol, smoking, and aflatoxin.
However, regardless of etiology, chronic liver diseases progress at
unequal rates in the two sexes, with the major sequelae, such as cirrhosis
and HCC, being more frequent in men than in women. These epidemiological
data have prompted researchers to investigate the relationship
between sex hormones and liver tumors. The human liver expresses estrogen
and androgen receptors and experimentally both androgens and estrogens have been implicated in stimulating hepatocyte proliferation
and may act as liver tumor inducers or promoters. (literal)
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