Induction of apoptosis and inhibition of cells growth in human hepatocellular carcinoma cells by COX-2 inhibitors. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Induction of apoptosis and inhibition of cells growth in human hepatocellular carcinoma cells by COX-2 inhibitors. (Articolo in rivista) (literal)

Anno

• 2004-01-01T00:00:00+01:00 (literal)

Alternative label

• Foderà D., D'Alessandro N., Cusimano A., Poma P., Notarbartolo M., Lampiasi N., Montalto G., Cervello M., (2004)
  Induction of apoptosis and inhibition of cells growth in human hepatocellular carcinoma cells by COX-2 inhibitors.
  in Annals of the New York Academy of Sciences
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Foderà D., D'Alessandro N., Cusimano A., Poma P., Notarbartolo M., Lampiasi N., Montalto G., Cervello M., (literal)

Pagina inizio

• 440 (literal)

Pagina fine

• 449 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 1028 (literal)

Rivista

• Annals of the New York Academy of Sciences (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Lampiasi Nadia, Cusimano Antonella, Cervello Melchiorre, IBIM CNR Poma Paola, D'Alessandro natale, Dipartimento di Scienze Farmacologiche università di palermo Montalto giuseppe Dipartimento di clinica Medica e Patologie Emergenti università di Palermo (literal)

Titolo

• Induction of apoptosis and inhibition of cells growth in human hepatocellular carcinoma cells by COX-2 inhibitors. (literal)

Abstract

• The aim of the present study was to examine the effects of nonselective (indomethacin) and selective cyclooxygenase-2 (COX-2) inhibitors (NS-398, nimesulide, and CAY10404) on cell growth, cell cycle distribution, and apoptosis in three human hepatocellular carcinoma cell lines (HepG2, HuH-6, and HA22T/VGH) with different characteristics of differentiation and biological behavior. The four COX inhibitors showed a dose-dependent growth-inhibitory effect in all the cell lines. No substantial arrests in the progression of the cells through the cell cycle were observed after treatment of HuH-6 or HA22T/VGH for 48 h with the various inhibitors. On the other hand, there were significant increases in apoptosis, with the highest effect of cell kill being seen after treatment with indomethacin, especially in HuH-6. Our findings support the suggestion that selective or, perhaps more efficiently, nonselective COX-2 inhibitors may have potential therapeutic effects in hepatocellular carcinoma. Further studies must be carried out to better determine the possible mechanisms of these effects. (literal)

Prodotto di

• Segnali cellulari critici nella biologia della cellula neoplastica (SV.P15.005.001) (Modulo)
• Istituto di biomedicina e di immunologia molecolare \"Alberto Monroy\" (IBIM) (Istituto)

Autore CNR

• MELCHIORRE CERVELLO (Persona)
• ANTONELLA CUSIMANO (Unità di personale interno)
• VERONICA POMA (Unità di personale esterno)
• Giuseppe Montalto (Persona)
• NATALE D'ALESSANDRO (Persona)
• NADIA LAMPIASI (Unità di personale interno)

Incoming links:

Autore CNR di

• MELCHIORRE CERVELLO (Persona)
• NADIA LAMPIASI (Unità di personale interno)
• NATALE D'ALESSANDRO (Persona)
• Giuseppe Montalto (Persona)
• VERONICA POMA (Unità di personale esterno)
• ANTONELLA CUSIMANO (Unità di personale interno)

Prodotto

• Istituto di biomedicina e di immunologia molecolare \"Alberto Monroy\" (IBIM) (Istituto)
• Segnali cellulari critici nella biologia della cellula neoplastica (SV.P15.005.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Annals of the New York Academy of Sciences (Rivista)