http://www.cnr.it/ontology/cnr/individuo/prodotto/ID122747
Cytomechanical modification induced by drug-loaded carriers uptake by breast cancer cells. (Abstract/Poster in atti di convegno)
- Type
- Label
- Cytomechanical modification induced by drug-loaded carriers uptake by breast cancer cells. (Abstract/Poster in atti di convegno) (literal)
- Anno
- 2009-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1007/s00249-009-0478-1 (literal)
- Alternative label
Vergaro V., Zacheo A., Bonsegna S., Palamà I.E., Zheng Z., Abdullayev E., Giovinazzo G., Cingolani R., Rinaldi R., Lvov Y.M., Santino A., Leporatti S. (2009)
Cytomechanical modification induced by drug-loaded carriers uptake by breast cancer cells.
in 7th European Biophysics Congress, Genova, July 11th-15th 2009
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Vergaro V., Zacheo A., Bonsegna S., Palamà I.E., Zheng Z., Abdullayev E., Giovinazzo G., Cingolani R., Rinaldi R., Lvov Y.M., Santino A., Leporatti S. (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- 38(Suppl 1):S35-S212 (literal)
- Rivista
- Note
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- 1National National Nanotechnology Laboratory (NNL) of CNR-INFM, University of Lecce, 73100 Lecce, Italy,
2Institute of Sciences of Food Production-C.N.R, 73100, Lecce, Italy,
3Institute for Micromanufacturing, Louisiana Tech University, Ruston, LA 71272, USA (literal)
- Titolo
- Cytomechanical modification induced by drug-loaded carriers uptake by breast cancer cells. (literal)
- Abstract
- The novel opportunities offered by the nanotechnologies have
attracted great interest in the development of novel biomaterials
for targeted drug delivery in cancer research. The
desired features of pharmaceutical drug delivery for intravenous
administration are their small size, biodegradability,
high drug content, prolonged circulation in the blood and
the ability to target required areas. In this work we have
compared efficacy of different type of carriers having complementary
properties for pharmaceutical delivery in cancer
therapy. Drug nano-colloids encapsulated by combination of
layer by layer (LbL) techniques and ultrasonication, phytochemical
encapsulated artificial oleosomes and drug-loading
clay/carbon nanotubes have been used for uptake into breast
cancer cells. Analysis of viscoelastic response of neoplastic
cells induced by cargo-carriers uptake has been carried out
by a combination of high resolution optical and scanning
force microscopy techniques. Furthermore, the effects of
drug-reservoir carriers on the cytoskeleton (re)organisation
of neoplastic cells were further investigated by confocal microscopy
using different fluorescent probes. (literal)
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