http://www.cnr.it/ontology/cnr/individuo/prodotto/ID12260
EGFR Signalling is required for Paracentrotus lividus endomesoderm specIF:ication. (Articolo in rivista)
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- Label
- EGFR Signalling is required for Paracentrotus lividus endomesoderm specIF:ication. (Articolo in rivista) (literal)
- Anno
- 2008-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1016/j.abb.2008.03.022 (literal)
- Alternative label
Romancino D.P.; Montana G.; Cavalieri V.; Spinelli G.; Di Carlo M. (2008)
EGFR Signalling is required for Paracentrotus lividus endomesoderm specIF:ication.
in Archives of biochemistry and biophysics (Print); Academic Press Elsevier, Inc., London (Regno Unito)
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- Romancino D.P.; Montana G.; Cavalieri V.; Spinelli G.; Di Carlo M. (literal)
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- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Titolo
- EGFR Signalling is required for Paracentrotus lividus endomesoderm specIF:ication. (literal)
- Abstract
- The EGFR pathway is critical for cell fate specification throughout the development of several organisms.
Here we identified in sea urchin an EGFR-related antigen maternally expressed and showing a dynamic
pattern of localization during development. To investigate the role played by the EGFR in Paracentrotus
lividus development we blocked its activity by using the EGFR kinase inhibitor AG1478. This treatment
produces decrease of EGFR phosphorylation, and embryos with various defects especially in the endomesoderm
territory until to obtain an animalized phenotype. These effects are rescued by the addition of
TGF-a, an EGFR ligand. The role played by EGFR-like along the animal/vegetal axis was also detected, after
AG1478 treatment, by the extended distribution of HE and decreased nuclearization of b-catenin in vegetal
cells. Moreover, inhibition of EGFR-like reduced ERK phosphorylation, necessary for cell fate specification
in the micromeres and their derivates. Taken together these results indicate that EGFR-like activity
is required both for A/V axis formation and endomesoderm differentiation. (literal)
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