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Supramaximal exercise mobilizes hematopoietic progenitors and reticulocytes in athletes (Articolo in rivista)
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- Label
- Supramaximal exercise mobilizes hematopoietic progenitors and reticulocytes in athletes (Articolo in rivista) (literal)
- Anno
- 2005-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1152/ajpregu.00338.2005 (literal)
- Alternative label
Giuseppe Morici,1,2; Daniele Zangla,1; Alessandra Santoro,3; Elvira Pelosi,4; Eleonora Petrucci,4;
Maria Gioia,5; Anna Bonanno,2; Mirella Profita,2; Vincenzo Bellia,6; Ugo Testa,4; and Maria R. Bonsignore2,6 (2005)
Supramaximal exercise mobilizes hematopoietic progenitors and reticulocytes in athletes
in American journal of physiology. Regulatory, integrative and comparative physiology
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Giuseppe Morici,1,2; Daniele Zangla,1; Alessandra Santoro,3; Elvira Pelosi,4; Eleonora Petrucci,4;
Maria Gioia,5; Anna Bonanno,2; Mirella Profita,2; Vincenzo Bellia,6; Ugo Testa,4; and Maria R. Bonsignore2,6 (literal)
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- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
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- PubMe (literal)
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- 1Department of Experimental Medicine, University of Palermo, Palermo, Italy; 2Institute of Biomedicine and Molecular
Immunology, Italian National Research Council, Palermo; 3Laboratory of Haematology, V. Cervello Hospital, Palermo;
4Dept of Hematology, Oncology and Molecular Medicine, Italian Institute of Public Health, Rome, Italy; 5Laboratory of
Clinical Pathology, V. Cervello Hospital, Palermo; and 6Institute of Medicine and Pneumology, University of Palermo, Italy (literal)
- Titolo
- Supramaximal exercise mobilizes hematopoietic progenitors and reticulocytes in athletes (literal)
- Abstract
- Marathon runners
show increased circulating CD34? cell counts and postexercise
release of interleukin-6 (IL-6), granulocyte-colony stimulating factor
(G-CSF) and flt3-ligand (Bonsignore MR, Morici G, Santoro A,
Pegano M, Cascio L, Bonnano A, Abate P, Mirabella F, Profita M,
Insalaco G, Gioia M, Vignola AM, Majolino I, Testa U, and Hogg JC.
J Appl Physiol 93: 1691-1697, 2002). In the present study we
hypothesized that supramaximal (\"all-out\") exercise may acutely
affect circulating progenitors and reticulocytes and investigated possible
mechanisms involved. Progenitor release was measured by flow
cytometry (n ? 20) and clonogenic assays (n ? 6) in 20 young
competitive rowers (13 M, 7 F, age ? SD: 17.1 ? 2.1 yr, peak O2
consumption: 56.5 ? 11.4 ml?min?1 ?kg?1) at rest and shortly after
1,000 m \"all-out.\" Release of reticulocytes, cortisol, muscle enzymes,
neutrophil elastase, and several cytokines/growth factors was measured.
Supramaximal exercise doubled circulating CD34? cells (rest:
7.6 ? 3.0, all-out: 16.3 ? 9.1 cells/?l, P ? 0.001), and increased
immature reticulocyte fractions; AC133? cells doubled, suggesting
release of angiogenetic precursors. Erythrocyte burst forming units
and colony forming units for granulocytes-monocytes and all blood
series increased postexercise by 3.4-, 5.5-, and 4.8-fold, respectively
(P ? 0.01 for all). All-out rowing acutely increased plasma cortisol,
neutrophil elastase, flt3-ligand, hepatocyte growth factor, VEGF, and
transforming growth factor-?1, and decreased erythropoietin; K-ligand,
stromal-derived factor-1, IL-6, and G-CSF were unchanged.
Therefore, all-out exercise is a physiological stimulus for progenitor
release in athletes. Release of reticulocytes and proangiogenetic cells
and mediators suggests tissue hypoxia as possibly involved in progenitor
mobilization. (literal)
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