http://www.cnr.it/ontology/cnr/individuo/prodotto/ID12192
Commitment and response to inductive signals of primary mesenchyme cells of the sea urchin embryo (Articolo in rivista)
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- Label
- Commitment and response to inductive signals of primary mesenchyme cells of the sea urchin embryo (Articolo in rivista) (literal)
- Anno
- 2004-01-01T00:00:00+01:00 (literal)
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- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Kiyomoto M; Zito F; Sciarrino S; Matranga V (literal)
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- Rivista
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- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Titolo
- Commitment and response to inductive signals of primary mesenchyme cells of the sea urchin embryo (literal)
- Abstract
- In the sea urchin embryo, primary mesenchyme cells (PMC) are committed to produce the larval skeleton,
although their behavior and skeleton production are influenced by signals from the embryonic environment.
Results from our recent studies showed that perturbation of skeleton development, by interfering with
ectoderm-extracellular matrix (ECM) interactions, is linked to a reduction in the gene expression of a
transforming growth factor (TGF)-beta growth factor,
Pl-univin
, suggesting a reduction in the blastocoelic
amounts of the protein and its putative involvement in signaling events. In the present study, we examined PMC
competence to respond to environmental signals in a validated skeleton perturbation model in
Paracentrotus
lividus
. We found that injection of blastocoelic fluid (BcF), obtained from normal embryos, into the blastocoelic
cavity of skeleton-defective embryos rescues skeleton development. In addition, PMC from skeleton-defective
embryos transplanted into normal or PMC-less blastula embryos are able to position in correct regions of the
blastocoel and to engage spicule elongation and patterning. Taken together, these results demonstrate that
PMC commitment to direct skeletogenesis is maintained in skeleton perturbed embryos and confirm the role
played by inductive signals in regulating skeleton growth and shape. (literal)
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