Atherosclerosis and the Glu298Asp polymorphism of the eNOS gene in white patients with end stage renal disease. (Articolo in rivista)

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Label
  • Atherosclerosis and the Glu298Asp polymorphism of the eNOS gene in white patients with end stage renal disease. (Articolo in rivista) (literal)
Anno
  • 2005-01-01T00:00:00+01:00 (literal)
Alternative label
  • Spoto B, Benedetto FA, Testa A, Tripepi G, Mallamaci F, Maas R, Boeger RH, Zoccali C, Parlongo RM, Pisano A. (2005)
    Atherosclerosis and the Glu298Asp polymorphism of the eNOS gene in white patients with end stage renal disease.
    in American journal of hypertension
    (literal)
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  • Spoto B, Benedetto FA, Testa A, Tripepi G, Mallamaci F, Maas R, Boeger RH, Zoccali C, Parlongo RM, Pisano A. (literal)
Pagina inizio
  • 1549 (literal)
Pagina fine
  • 1555 (literal)
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  • 18 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
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  • CNR, IBIM, Natl Res Council, Inst Biochem, Reggio Di Calabria, Italy Morelli Hosp, Cardiol Unit, Reggio Di Calabria, Italy Univ Hamburg Hosp, Clin Pharmacol Unit, Dept Pharmacol, D-2000 Hamburg, Germany (literal)
Titolo
  • Atherosclerosis and the Glu298Asp polymorphism of the eNOS gene in white patients with end stage renal disease. (literal)
Abstract
  • Background: We investigated whether the eNOS G/T polymorphism (Glu298Asp variant) is linked to the severity of carotid atherosclerosis and whether it is independent of asymmetric dimethylarginine (ADMA) in determining vascular damage in patients with end-stage renal disease (ESRD). Methods: The eNOS polymorphism, ADMA, carotid intima-media thickness (IMT), and carotid artery (CCA) wall-to-lumen ratio (an indicator of arterial remodeling) were determined/measured in 131 patients with ESRD. Results: Both in the co-dominant and dominant model approach. IMT as well as CCA wall-to-lumen ratio were directly related to the T allele (P <= .009) and these relationships held true in multiple linear regression analyses including ADMA and traditional and emerging risk factors. The relationship between eNOS genotypes and CCA wall-to-lumen ratio was further analyzed by a categorical approach and in a multiple logistic regression analysis, the odds ratio (OR) of increased CCA wall-to-lumen ratio was strongly associated to the T allele (codominant model: GG, OR = 1; GT, OR = 2.1;TT, OR = 8.2; P for trend = .01; dominant model: GG, OR = 1; GT and TT, OR = 2.7; P = .02). Conclusions: The T allele of eNOS gene is an independent predictor of intimal lesions and vascular remodeling and it is associated with the severity of atherosclerosis independently of ADMA (literal)
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