Bronchial hyperresponsiveness in children with atopic rhinitis: a seven-year follow-up (Articolo in rivista)

Type
Label
  • Bronchial hyperresponsiveness in children with atopic rhinitis: a seven-year follow-up (Articolo in rivista) (literal)
Anno
  • 2004-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1111/j.1398-9995.2004.00559.x (literal)
Alternative label
  • Cibella F; Cuttitta G; La Grutta S; Hopps MR; Passalacqua G; Pajno GB; Bonsignore G (2004)
    Bronchial hyperresponsiveness in children with atopic rhinitis: a seven-year follow-up
    in Allergy (Cph.)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Cibella F; Cuttitta G; La Grutta S; Hopps MR; Passalacqua G; Pajno GB; Bonsignore G (literal)
Pagina inizio
  • 1074 (literal)
Pagina fine
  • 1079 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 59 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 10 (literal)
Note
  • PubMe (literal)
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Istituto di Biomedicina e Immunologia Molecolare del Consiglio Nazionale delle Ricerche, Palermo ARPA Sicilia, Palermo (literal)
Titolo
  • Bronchial hyperresponsiveness in children with atopic rhinitis: a seven-year follow-up (literal)
Abstract
  • Background: A high prevalence of bronchial hyperresponsiveness (BHR) was found in atopic subjects with rhinitis. Those subjects may be at higher risk for developing bronchial asthma. We evaluated, in a 7-year follow-up, BHR and atopy in a homogeneous population of nonasthmatic children with allergic rhinitis (AR), and their role in asthma development. Methods: Twenty-eight children (6-15 years) with AR were studied. At enrollment (T-0), skin tests, total serum IgE assay, peak expiratory flow (PEF) monitoring and methacholine (Mch) bronchial challenge were performed. BHR was computed as the Mch dose causing a 20% forced expiratory volume (FEV)(1) fall (PD20FEV1) and as dose-response slope (D-RS). Subjects were reassessed after 7 years (T-1) using the same criteria. Results: At T-0, 13 children (46%), showing a PD20FEV1 <1526 mug of Mch, had BHR (Mch+), although PEF variability (PEFv) was within normal limits. None of the children with negative methacholine test developed bronchial asthma after 7 years. Of the 13 Mch+, only two reported asthma symptoms after 7 years. No significant change was seen in the other parameters of atopy considered. Conclusion: Children with allergic rhinitis present a high prevalence of BHR. Nevertheless, their PEFv is normal and the rate of asthma development low. (literal)
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