http://www.cnr.it/ontology/cnr/individuo/prodotto/ID12186
Bronchial hyperresponsiveness in children with atopic rhinitis: a seven-year follow-up (Articolo in rivista)
- Type
- Label
- Bronchial hyperresponsiveness in children with atopic rhinitis: a seven-year follow-up (Articolo in rivista) (literal)
- Anno
- 2004-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1111/j.1398-9995.2004.00559.x (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Cibella F; Cuttitta G; La Grutta S; Hopps MR; Passalacqua G; Pajno GB; Bonsignore G (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
- Note
- PubMe (literal)
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Istituto di Biomedicina e Immunologia Molecolare del Consiglio Nazionale delle Ricerche, Palermo
ARPA Sicilia, Palermo (literal)
- Titolo
- Bronchial hyperresponsiveness in children with atopic rhinitis: a seven-year follow-up (literal)
- Abstract
- Background: A high prevalence of bronchial hyperresponsiveness (BHR) was found in atopic subjects with rhinitis. Those subjects may be at higher risk for developing bronchial asthma. We evaluated, in a 7-year follow-up, BHR and atopy in a homogeneous population of nonasthmatic children with allergic rhinitis (AR), and their role in asthma development.
Methods: Twenty-eight children (6-15 years) with AR were studied. At enrollment (T-0), skin tests, total serum IgE assay, peak expiratory flow (PEF) monitoring and methacholine (Mch) bronchial challenge were performed. BHR was computed as the Mch dose causing a 20% forced expiratory volume (FEV)(1) fall (PD20FEV1) and as dose-response slope (D-RS). Subjects were reassessed after 7 years (T-1) using the same criteria.
Results: At T-0, 13 children (46%), showing a PD20FEV1 <1526 mug of Mch, had BHR (Mch+), although PEF variability (PEFv) was within normal limits. None of the children with negative methacholine test developed bronchial asthma after 7 years. Of the 13 Mch+, only two reported asthma symptoms after 7 years. No significant change was seen in the other parameters of atopy considered.
Conclusion: Children with allergic rhinitis present a high prevalence of BHR. Nevertheless, their PEFv is normal and the rate of asthma development low. (literal)
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