http://www.cnr.it/ontology/cnr/individuo/prodotto/ID12177
LTB4 is present in exudative pleural effusions and actively contributes to neutrophil recruitment in the inflamed pleural space (Articolo in rivista)
- Type
- Label
- LTB4 is present in exudative pleural effusions and actively contributes to neutrophil recruitment in the inflamed pleural space (Articolo in rivista) (literal)
- Anno
- 2004-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1111/j.1365-2249.2004.02387.x (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- E. PACE*; M. PROFITA*; M. MELIS*; A. BONANNO*; A. PATERNÒ+; C. H. MODY?; M. SPATAFORA+; M. FERRARO*;
L. SIENA*; A. M. VIGNOLA*+; G. BONSIGNORE*; & M. GJOMARKAJ* (literal)
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- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
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- ISI Web of Science (WOS) (literal)
- PubMe (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- *Istituto di Biomedicina e Immunologia Molecolare,Consiglio Nazionale delle Ricerche, Palermo,
+Istituto di Medicina Generale e Pneumologia, Università degli Studi, Palermo, Italy, and
?Departments of Internal Medicine and Microbiology and Infectious Diseases, University of Calgary, Alberta, Canada (literal)
- Titolo
- LTB4 is present in exudative pleural effusions and actively contributes to neutrophil recruitment in the inflamed pleural space (literal)
- Abstract
- The pleural space is a virtual compartment between the lung and chest wall that becomes filled with fluid and inflammatory cells during a variety of respiratory diseases. Here, we study the potential role of the eicosanoid metabolite leukotriene B4 (LTB4) in disparate diseases leading to acute (pneumonia) or chronic (tuberculosis, cancer) inflammation of the pleural space. LTB4 concentrations were significantly higher in pleural fluid due to pneumonia, tuberculosis and cancer with respect to congestive heart failure and correlated with neutrophil elastase, which is used as an indication of state of activation of neutrophils in the pleural space. Moreover, pleural LTB4
was biologically active, as an anti-LTB4 antibody partially neutralized the chemotactic activity of parapneumonic, tuberculous and cancer effusions. Macrophages, neutrophils, lymphocytes, mesothelial cells and cancer cells all expressed mRNA for 5-lipoxygenase, the enzyme that initiates leukotriene synthesis leading to the production of LTB4, in exudative pleural effusions. Upon stimulation in transudative pleural effusions, pleural macrophages produced, in a time-dependent fashion, a significantly higher concentration of LTB4 than mesothelial cells.
These studies demonstrate that different cell types are capable of producing LTB4 in the inflamed pleural
space and that this mediator may play a crucial role in the recruitment of neutrophils into the pleural space. (literal)
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