http://www.cnr.it/ontology/cnr/individuo/prodotto/ID12144
Immunoregulatory role of Jalpha281 T cells in aged mice developing lupus-like nephritis (Articolo in rivista)
- Type
- Label
- Immunoregulatory role of Jalpha281 T cells in aged mice developing lupus-like nephritis (Articolo in rivista) (literal)
- Anno
- 2007-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1002/eji.200636695 (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Guido Sireci 1; Domenica Russo 2; Francesco Dieli 1; Steven A. Porcelli 3;
Masaru Taniguchi 4; Marco Pio La Manna 1; Diana Di Liberto 1;
Francesco Scarpa 1 and Alfredo Salerno 1 (literal)
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- Rivista
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- 1 Dipartimento di Biopatologia e Metodologie Biomediche, Universit? di Palermo,
Palermo, Italy
2 Istituto di Biologia e Immunologia Molecolare, Consiglio Nazionale delle Ricerche,
Palermo, Italy
3 Department of Microbiology and Immunology, Albert Einstein College of Medicine,
Bronx, NY, USA
4 Research Unit for Cellular Immunotherapy, RIKEN Research Center for Allergy and
Immunology, Yokohama, Kanagawa, Japan (literal)
- Titolo
- Immunoregulatory role of Jalpha281 T cells in aged mice developing lupus-like nephritis (literal)
- Abstract
- Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the
emergence of autoreactive Tcells. Humans and mice with SLE have reduced numbers of
CD1d-restricted invariant natural killer T (iNKT) cells, suggesting a key role for these
cells in its immunopathogenesis. This subset uses an invariant TCR constituted by
Va14Ja281 chains paired with some Vb domains. The regulatory role for iNKT cells in
non-autoimmune mice was suggested by our previous results showing that aged Ja281
knockout (KO) mice produce anti-dsDNA. Here we show that old Ja281 KO mice have
proteinuria and antibodies against dsDNA and cardiolipin. Histological analysis of
Ja281 KO mice revealed glomeruli damage and deposition of C3c and IgG, mainly of the
IgG3 subclass. In spleens of aged Ja281 KO mice there is an increase of activated
marginal zone B cells. The evolution of lesions may depend on the age-associated
increase of autoantibodies production, preferentially IgG3, mainly secreted by marginal
zone B cells. Our results provide the first evidence of a lupus-like syndrome in nonautoimmune
mice, supporting an age-related immunoregulatory role of Ja281+ cells,
probably associated with the activation of marginal zone B cells. (literal)
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