Histamine and spontaneously released mast cell granules affect the cell growth of human hepatocellular carcinoma cells (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Histamine and spontaneously released mast cell granules affect the cell growth of human hepatocellular carcinoma cells (Articolo in rivista) (literal)

Anno

• 2007-01-01T00:00:00+01:00 (literal)

Alternative label

• Lampiasi N, Azzolina A, Montalto G, Cervello M. (2007)
  Histamine and spontaneously released mast cell granules affect the cell growth of human hepatocellular carcinoma cells
  in Experimental and Molecular Medicine
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Lampiasi N, Azzolina A, Montalto G, Cervello M. (literal)

Pagina inizio

• 248 (literal)

Pagina fine

• 294 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 39 (literal)

Rivista

• Experimental and Molecular Medicine (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Lampiasi Nadia, Azzolina Antonina, Cervello Melchiorre, IBIM CNR (literal)

Titolo

• Histamine and spontaneously released mast cell granules affect the cell growth of human hepatocellular carcinoma cells (literal)

Abstract

• The role of mast cells in tumor growth is still controversial. In this study we analyzed the effects of both histamine and pre-formed mediators spontaneously released by mast cells on the growth of two human hepatocellular carcinoma cell lines, HA22T/VGH and HuH-6, with different characteristics of differentiation, biological behavior and genetic defects. We showed that total mast cell releasate, exocytosed granules (granule remnants) and histamine reduced cell viability and proliferation in HuH-6 cells. In contrast, in HA22T/VGH cells granule remnants and histamine induced a weak but significant increase in cell growth. We showed that both cell lines expressed histamine receptors H1 and H2 and that the selective H1 antagonist terfenadine reverted the histamine-induced inhibition of HuH-6 cell growth, whereas the selective H2 antagonist ranitidine inhibited the histamine-induced cell growth of HA22T/VGH cells. We demonstrated that histamine down-regulated the expression of ?-ca - tenin, COX-2 and survivin in HuH-6 cells and that this was associated with caspase-3 activation and PARP cleavage. On the contrary, in HA22T/VGH cells expression of survivin and ?-catenin increased after treatment with granule remnants and histamine. Overall, our results suggest that mediators stored in mast cell granules and histamine may affect the growth of liver cancer cells. However, mast cells and histamine may play different roles depending on the tumor cell features. Finally, these data suggest that histamine and histamine receptor agonists/ antagonists might be considered as \"new therapeutic\" drugs to inhibit liver tumor growth. (literal)

Prodotto di

• Segnali cellulari critici nella biologia della cellula neoplastica (SV.P15.005.001) (Modulo)
• Istituto di biomedicina e di immunologia molecolare \"Alberto Monroy\" (IBIM) (Istituto)

Autore CNR

• MELCHIORRE CERVELLO (Persona)
• NADIA LAMPIASI (Unità di personale interno)
• ANTONINA AZZOLINA (Persona)

Incoming links:

Autore CNR di

• MELCHIORRE CERVELLO (Persona)
• NADIA LAMPIASI (Unità di personale interno)
• ANTONINA AZZOLINA (Persona)

Prodotto

• Istituto di biomedicina e di immunologia molecolare \"Alberto Monroy\" (IBIM) (Istituto)
• Segnali cellulari critici nella biologia della cellula neoplastica (SV.P15.005.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Experimental and Molecular Medicine (Rivista)