http://www.cnr.it/ontology/cnr/individuo/prodotto/ID12094
The selective cyclooxygenase-1 inhibitor SC-560 suppresses cell proliferation and induces apoptosis in human hepatocellular carcinoma cells (Articolo in rivista)
- Type
- Label
- The selective cyclooxygenase-1 inhibitor SC-560 suppresses cell proliferation and induces apoptosis in human hepatocellular carcinoma cells (Articolo in rivista) (literal)
- Anno
- 2006-01-01T00:00:00+01:00 (literal)
- Alternative label
Lampiasi N, Foderà D, D'Alessandro N, Cusimano A, Azzolina A, Tripodo C, Florena A.M, Minervini M.I, Notarbartolo M, Montalto G, Cervello M. (2006)
The selective cyclooxygenase-1 inhibitor SC-560 suppresses cell proliferation and induces apoptosis in human hepatocellular carcinoma cells
in International Journal of Molecular Medicine
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Lampiasi N, Foderà D, D'Alessandro N, Cusimano A, Azzolina A, Tripodo C, Florena A.M, Minervini M.I, Notarbartolo M, Montalto G, Cervello M. (literal)
- Pagina inizio
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Lampiasi Nadia, Cusimano Antonella, Azzolina Antonina, Cervello Melchiorre, IBIM CNR (literal)
- Titolo
- The selective cyclooxygenase-1 inhibitor SC-560 suppresses cell proliferation and induces apoptosis in human hepatocellular carcinoma cells (literal)
- Abstract
- Abstract. Two isoforms of cyclooxygenase (COX) are
known, and to date most studies have implicated COX-2 in
the development and progression of various human cancers.
Increasing evidence suggests that COX-1 may also play a
similar role. Indeed, we have recently observed that the
dual COX-1/COX-2 inhibitor indomethacin induces apoptosis
in human hepatocellular carcinoma (HCC) cell lines more
effectively than the selective COX-2 inhibitors, possibly
implicating COX-1 in HCC. In this study we investigated the
expression of COX-1 in non-tumor and malignant human
liver tissues, as well as the effects of the highly selective
COX-1 inhibitor SC-560 on cell growth and apoptosis in
human HCC cell lines. Expression of COX-1 was detected
in nearly all the samples assayed, although with a high
variability between non-tumoral (NT) and malignant tissues.
The percentage of COX-1 positive cells was significantly
higher in the NT tissues than in the tumors (p<0.0001). In
well-differentiated HCC COX-1 expression was significantly
higher than in the poorly-differentiated tissues (p<0.05). SC-
560 showed a dose- and time-dependent inhibitory effect on
HCC cell growth. The combination of the COX-1 inhibitor with
nimesulide and CAY10404, two selective COX-2 inhibitors,
resulted in additive effects on cell growth inhibition. SC-560
also inhibited colony formation in soft agar and induced
apoptosis in HCC cells in a dose-dependent manner. Moreover,
SC-560 decreased the levels of the anti-apoptotic proteins
survivin and XIAP and activated caspase-3 and -7 in a doseand
time-dependent fashion. In conclusion, we report for the
first time that the selective COX-1 inhibitor SC-560 exhibits
anti-tumor and apoptotic effects in human HCC cells. Overall,
our previous and present results suggest that both COX-1 and
COX-2 inhibitors may have potential therapeutic implications
in HCC patients. (literal)
- Prodotto di
- Autore CNR
Incoming links:
- Autore CNR di
- Prodotto
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi