Noninvasive methods for the detection of upper and lower airway inflammation in atopic children. (Articolo in rivista)

Type
Label
  • Noninvasive methods for the detection of upper and lower airway inflammation in atopic children. (Articolo in rivista) (literal)
Anno
  • 2006-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.jaci.2006.07.028 (literal)
Alternative label
  • Mirella Profita, PhD,a; Stefania La Grutta, MD,b; Elisiana Carpagnano, MD,c; Loredana Riccobono, PhD,a; Rossana Di Giorgi, PhD,a; Anna Bonanno, PhD,a; Elisabetta Pace, MD,a; Giovanni Bonsignore, MD,a; Jean Bousquet, MD,d; Antonio Maurizio Vignola, MD,PhD,a; Mark Gjomarkaj, MDa. (2006)
    Noninvasive methods for the detection of upper and lower airway inflammation in atopic children.
    in Journal of allergy and clinical immunology
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Mirella Profita, PhD,a; Stefania La Grutta, MD,b; Elisiana Carpagnano, MD,c; Loredana Riccobono, PhD,a; Rossana Di Giorgi, PhD,a; Anna Bonanno, PhD,a; Elisabetta Pace, MD,a; Giovanni Bonsignore, MD,a; Jean Bousquet, MD,d; Antonio Maurizio Vignola, MD,PhD,a; Mark Gjomarkaj, MDa. (literal)
Pagina inizio
  • 1068 (literal)
Pagina fine
  • 1074 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 118 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 7 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 5 (literal)
Note
  • Pubmed (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • a the Institute of Biomedicine and Molecular Immunology, Section of Immunopathology and Clinical and Experimental Pharmacology of the Respiratory System, Italian National Research Council, Palermo; b the Allergy Unit, Children Hospital, ARNAS, Palermo; c the Institute of Respiratory Diseases, University of Bari; and d Institut National de la Sante` et de la Recherche Medical U-454, Montpellier. (literal)
Titolo
  • Noninvasive methods for the detection of upper and lower airway inflammation in atopic children. (literal)
Abstract
  • Background: Exhaled nitric oxide (FENO) and exhaled breath condensate (EBC) are noninvasive methods to assess inflammation. Objective: To investigate the role of the FENO and of the EBC pH and IL-5 levels in atopic children. Methods: We evaluated oral and nasal FENO and the pH and IL-5 of oral and nasal EBC in children with atopic dermatitis (AD; n 5 18), allergic rhinitis (AR; n 5 18), intermittent asthma (n 5 21), moderate persistent asthma (n 5 18), and healthy controls (HCs; n 5 16). Results: Oral FENO was significantly increased in asthma, whereas the nasal values were increased in AR and asthma in comparison with HCs. The pH of oral EBC was lower in AD and asthma than in AR and HCs, whereas the nasal levels were lower in AD, AR, and asthma than in HCs. The oral IL-5 was higher in AD, AR, and asthma in comparison with HCs, whereas the nasal IL-5 concentrations were higher in asthma and AR than in HCs. In AR, the nasal FENO correlated with the IL-5 values and with the disease duration. In intermittent asthma, oral and nasal pH inversely correlated with the exacerbations, whereas in moderate asthma, the nasal IL-5 positively correlated with exacerbations. In AD, the oral and nasal IL-5 positively correlated with the serum IgE. Conclusion: These markers of nasal and bronchial inflammation, accessible with noninvasive techniques, might be useful to identify patients with uncontrolled diseases and to verify the usefulness of new therapeutic approaches. Clinical implications: These markers are useful tools to monitor the upper and lower airway inflammation in atopic children. (J Allergy Clin Immunol 2006;118:1068-74.) (literal)
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