http://www.cnr.it/ontology/cnr/individuo/prodotto/ID12084
Noninvasive methods for the detection of upper and lower airway inflammation in atopic children. (Articolo in rivista)
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- Label
- Noninvasive methods for the detection of upper and lower airway inflammation in atopic children. (Articolo in rivista) (literal)
- Anno
- 2006-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1016/j.jaci.2006.07.028 (literal)
- Alternative label
Mirella Profita, PhD,a; Stefania La Grutta, MD,b; Elisiana Carpagnano, MD,c; Loredana Riccobono, PhD,a; Rossana Di Giorgi, PhD,a; Anna Bonanno, PhD,a; Elisabetta Pace, MD,a; Giovanni Bonsignore, MD,a; Jean Bousquet, MD,d; Antonio Maurizio Vignola, MD,PhD,a; Mark Gjomarkaj, MDa. (2006)
Noninvasive methods for the detection of upper and lower airway inflammation in atopic children.
in Journal of allergy and clinical immunology
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Mirella Profita, PhD,a; Stefania La Grutta, MD,b; Elisiana Carpagnano, MD,c; Loredana Riccobono, PhD,a; Rossana Di Giorgi, PhD,a; Anna Bonanno, PhD,a; Elisabetta Pace, MD,a; Giovanni Bonsignore, MD,a; Jean Bousquet, MD,d; Antonio Maurizio Vignola, MD,PhD,a; Mark Gjomarkaj, MDa. (literal)
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- a the Institute of Biomedicine and Molecular Immunology, Section of Immunopathology and Clinical and Experimental Pharmacology of the
Respiratory System, Italian National Research Council, Palermo;
b the Allergy Unit, Children Hospital, ARNAS, Palermo;
c the Institute of Respiratory Diseases, University of Bari; and
d Institut National de la Sante` et de la Recherche Medical U-454, Montpellier. (literal)
- Titolo
- Noninvasive methods for the detection of upper and lower airway inflammation in atopic children. (literal)
- Abstract
- Background: Exhaled nitric oxide (FENO) and exhaled breath
condensate (EBC) are noninvasive methods to assess
inflammation.
Objective: To investigate the role of the FENO and of the EBC
pH and IL-5 levels in atopic children.
Methods: We evaluated oral and nasal FENO and the pH and
IL-5 of oral and nasal EBC in children with atopic dermatitis
(AD; n 5 18), allergic rhinitis (AR; n 5 18), intermittent
asthma (n 5 21), moderate persistent asthma (n 5 18), and
healthy controls (HCs; n 5 16).
Results: Oral FENO was significantly increased in asthma,
whereas the nasal values were increased in AR and asthma
in comparison with HCs. The pH of oral EBC was lower in
AD and asthma than in AR and HCs, whereas the nasal
levels were lower in AD, AR, and asthma than in HCs.
The oral IL-5 was higher in AD, AR, and asthma in
comparison with HCs, whereas the nasal IL-5 concentrations
were higher in asthma and AR than in HCs. In AR, the nasal
FENO correlated with the IL-5 values and with the disease
duration. In intermittent asthma, oral and nasal pH inversely
correlated with the exacerbations, whereas in moderate
asthma, the nasal IL-5 positively correlated with exacerbations.
In AD, the oral and nasal IL-5 positively correlated with the
serum IgE.
Conclusion: These markers of nasal and bronchial
inflammation, accessible with noninvasive techniques,
might be useful to identify patients with uncontrolled
diseases and to verify the usefulness of new therapeutic
approaches.
Clinical implications: These markers are useful tools to
monitor the upper and lower airway inflammation in atopic
children. (J Allergy Clin Immunol 2006;118:1068-74.) (literal)
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