http://www.cnr.it/ontology/cnr/individuo/prodotto/ID12073
The E-selectin gene polymorphism and carotid atherosclerosis in end-stage renal disease. (Articolo in rivista)
- Type
- Label
- The E-selectin gene polymorphism and carotid atherosclerosis in end-stage renal disease. (Articolo in rivista) (literal)
- Anno
- 2006-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1093/ndt/gfl115 (literal)
- Alternative label
Testa A, Benedetto FA, Spoto B, Pisano A, Tripepi G, Mallamaci F, Malatino LS, Zoccali C. (2006)
The E-selectin gene polymorphism and carotid atherosclerosis in end-stage renal disease.
in Nephrology dialysis transplantation (Online)
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Testa A, Benedetto FA, Spoto B, Pisano A, Tripepi G, Mallamaci F, Malatino LS, Zoccali C. (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- CNR, Inst Biomed Clin Epidemiol & Physiopathol Renal D, CNR IBIM, Reggio Di Calabria, Italy
Univ Catania, Dept Internal Med, I-95124 Catania, Italy (literal)
- Titolo
- The E-selectin gene polymorphism and carotid atherosclerosis in end-stage renal disease. (literal)
- Abstract
- Background. E-selectin is a cell surface glycoprotein
that mediates the adhesion of leucocytes to
vessels endothelium, an important early step in the
atherosclerotic process. End-stage renal disease
(ESRD) is a highly atherogenic disease but it is
unknown whether genetic polymorphism(s) in the
E-selectin gene plays a role in the severity of arterial
damage in this condition.
Method. In this study, we tested whether the
Leu554Phe variant in the E-selectin gene is linked to
carotid atherosclerosis in 134 well-characterized ESRD
patients. The frequency of this polymorphism was
also measured in a population sample of the same
geographical area.
Results. A total of 84% patients had the CC genotype,
13% had the CT genotype, 3% had the TT genotype
and this distribution did not differ from that in the
control population. Intima-media thickness (IMT)
(P¼0.01) and cross-sectional area (P¼0.02) were
significantly higher in patients with the T-allele than
in those without this allele. Furthermore, the degree
of carotid stenosis was significantly higher (P¼0.02)
in patients with T-allele than in CC patients.
On multivariate analyses including the traditional
and non-traditional risk factors, the Leu554Phe polymorphism
was confirmed as an independent correlate
of IMT (P¼0.02), cross-sectional area (P¼0.03)
and carotid stenosis (P¼0.02).
Conclusion. In ESRD, the Leu554Phe polymorphism
of E-selectin gene is associated with the severity of
carotid atherosclerosis, suggesting that geneticallydetermined
alterations in the E-selectin molecule may
render ESRD patients with this gene variant particularly
susceptible to the detrimental effects of inflammation
on the arterial wall. (literal)
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