A caspase-3-dependent pathway is predominantly activated by the excitotoxin pregnenolone sulfate and requires early and late cytochrome c release and cell-speci.c caspase-2 activation in the retinal cell death (Articolo in rivista)

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  • A caspase-3-dependent pathway is predominantly activated by the excitotoxin pregnenolone sulfate and requires early and late cytochrome c release and cell-speci.c caspase-2 activation in the retinal cell death (Articolo in rivista) (literal)
Anno
  • 2002-01-01T00:00:00+01:00 (literal)
Alternative label
  • Cascio C., Guarneri R., Russo D., De Leo G., Guarneri M., Piccoli' F., Guarneri P. (2002)
    A caspase-3-dependent pathway is predominantly activated by the excitotoxin pregnenolone sulfate and requires early and late cytochrome c release and cell-speci.c caspase-2 activation in the retinal cell death
    in Journal of neurochemistry
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Cascio C., Guarneri R., Russo D., De Leo G., Guarneri M., Piccoli' F., Guarneri P. (literal)
Pagina inizio
  • 1358 (literal)
Pagina fine
  • 1371 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 83 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note
  • Impact Factor: 4.834 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#descrizioneSinteticaDelProdotto
  • Identificazione di pathways apoptotici in retine sottoposte a eccitotossicità e ruolo protettivo del 17-beta estradiolo (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Dipartimento di Biopatologia e Metodologie Biomediche e Istituto di Neuropsichiatria, Facoltà di Medicina e Chirurgia, Università di Palermo, Palermo, Italy (literal)
Titolo
  • A caspase-3-dependent pathway is predominantly activated by the excitotoxin pregnenolone sulfate and requires early and late cytochrome c release and cell-speci.c caspase-2 activation in the retinal cell death (literal)
Abstract
  • This study investigates the implication of mitochondria- and caspase-dependent pathways in the death of retinal neurones exposed to the neurosteroid pregnenolone sulfate (PS) shown to evoke apoptosis and contribute to amplification and propagation of excitotoxicity. After a brief PS challenge of intact retinas, caspase-3 and caspase-2 activation and cytochrome c release occur early and independent of changes in the oxidative state measured by superoxide dismutase activity. The temporal and spatial relationship of these events suggests that a caspase-3-dependent pathway is activated in response to cytochrome c release and requires caspase-2 activation and a late cytochrome c release in specific cellular subsets of retinal layers. The protection by caspase inhibitors indicates a predominant role of the pathway in PS-induced retinal apoptosis, although a limited use of caspase inhibitors is upheld on a conceivable shift from apoptosis toward necrosis. Conversely, 3a-hydroxy-5b-pregnan-20-one sulfate and 17b-oestradiol provide complete prevention of PSinduced retinal death. (literal)
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