http://www.cnr.it/ontology/cnr/individuo/prodotto/ID12040
A caspase-3-dependent pathway is predominantly activated by the excitotoxin pregnenolone sulfate and requires early and late cytochrome c release and cell-speci.c caspase-2 activation in the retinal cell death (Articolo in rivista)
- Type
- Label
- A caspase-3-dependent pathway is predominantly activated by the excitotoxin pregnenolone sulfate and requires early and late cytochrome c release and cell-speci.c caspase-2 activation in the retinal cell death (Articolo in rivista) (literal)
- Anno
- 2002-01-01T00:00:00+01:00 (literal)
- Alternative label
Cascio C., Guarneri R., Russo D., De Leo G., Guarneri M., Piccoli' F., Guarneri P. (2002)
A caspase-3-dependent pathway is predominantly activated by the excitotoxin pregnenolone sulfate and requires early and late cytochrome c release and cell-speci.c caspase-2 activation in the retinal cell death
in Journal of neurochemistry
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Cascio C., Guarneri R., Russo D., De Leo G., Guarneri M., Piccoli' F., Guarneri P. (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note
- Impact Factor: 4.834 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#descrizioneSinteticaDelProdotto
- Identificazione di pathways apoptotici in retine sottoposte a eccitotossicità e ruolo protettivo del 17-beta estradiolo (literal)
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Dipartimento di Biopatologia e Metodologie Biomediche e Istituto di Neuropsichiatria, Facoltà di Medicina e Chirurgia, Università di Palermo, Palermo, Italy (literal)
- Titolo
- A caspase-3-dependent pathway is predominantly activated by the excitotoxin pregnenolone sulfate and requires early and late cytochrome c release and cell-speci.c caspase-2 activation in the retinal cell death (literal)
- Abstract
- This study investigates the implication of mitochondria- and
caspase-dependent pathways in the death of retinal neurones
exposed to the neurosteroid pregnenolone sulfate (PS) shown
to evoke apoptosis and contribute to amplification and propagation
of excitotoxicity. After a brief PS challenge of intact
retinas, caspase-3 and caspase-2 activation and cytochrome
c release occur early and independent of changes in
the oxidative state measured by superoxide dismutase activity.
The temporal and spatial relationship of these events
suggests that a caspase-3-dependent pathway is activated in
response to cytochrome c release and requires caspase-2
activation and a late cytochrome c release in specific cellular
subsets of retinal layers. The protection by caspase inhibitors
indicates a predominant role of the pathway in PS-induced
retinal apoptosis, although a limited use of caspase inhibitors
is upheld on a conceivable shift from apoptosis toward necrosis.
Conversely, 3a-hydroxy-5b-pregnan-20-one sulfate and
17b-oestradiol provide complete prevention of PSinduced
retinal death. (literal)
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